{"product_id":"abcam-ab264783","title":"Abcam, ab264783, Human NLGN4X knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nNLGN4X KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 2 and Insertion of the selection cassette in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 2 and Insertion of the selection cassette in exon 2,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-NLGN4X, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNLGN4X also known as neuroligin 4X is a protein that plays a critical role in synaptic function and signaling in the human brain. This protein with a molecular mass of approximately 91 kDa is part of the neuroligin family which includes several proteins integral to the formation and maintenance of synapses. It is predominantly expressed in the central nervous system particularly in areas where neuronal communication is essential. NLGN4X assists in the important task of cell–cell interaction at synaptic junctions promoting synaptic stability and ensuring efficient neurotransmission.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNLGN4X participates in the maintenance of synaptic function both in excitatory and inhibitory synapses. It forms part of a larger synaptic complex that includes neurexins and other proteins essential for synaptic adhesion and signal transduction. These complexes are necessary for precise neurotransmitter release and reception allowing neurons to reliably and efficiently communicate. The structural integrity provided by NLGN4X's presence in these complexes underlies normal synaptic operation and influences cognitive processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuroligins belong to multiple neurological pathways emphasizing their role in synaptic organization and plasticity. NLGN4X engages with pathways like the synaptic vesicle cycle and postsynaptic density dynamics vital for modulating synaptic strength and plasticity. Through these pathways NLGN4X interacts closely with proteins such as neurexins facilitating synaptic organization and communication that are fundamental in neural network function.\u003cbr\u003e\nAlterations in NLGN4X are strongly associated with autism spectrum disorders and intellectual disability. Mutations or deletions within the NLGN4X gene can disrupt normal synaptic connectivity leading to impaired social behavior and cognitive functions inherent in these disorders. NLGN4X is intertwined with other proteins such as SHANK3 both linked to synaptic stability and function. Disruption in their interactions can exacerbate synaptic and functional deficits observed in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845157048489,"sku":"ab264783","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab264783","provider":"Iright","version":"1.0","type":"link"}