{"product_id":"abcam-ab265300","title":"Abcam, ab265300, Human BTN3A2 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nBTN3A2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 11 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 11 bp deletion in exon 2,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-BTN3A2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBTN3A2 also known as Butyrophilin Subfamily 3 Member A2 is a protein involved in the immune response. It has a molecular weight of approximately 35 kDa. BTN3A2 expresses in a variety of tissues especially in immune-related cells like T-cells. It forms part of the butyrophilin family known for modulating immune cell functions. The protein is anchored in the cell membrane indicating its role in cell signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBTN3A2 participates in immune regulation and modulation of T-cell activity. It functions as part of the BTN3A family complex working alongside BTN3A1 and BTN3A3. This protein family influences T-cell receptor signaling and activation contributing to the immune system's ability to respond to pathogens and infections. BTN3A2 plays a role in linking extracellular and intracellular signals that affect immune cell behavior.\u003cbr\u003e\nPathways\u003cbr\u003e\nBTN3A2 integrates within the adaptive immune signaling pathways. One key pathway is the T-cell receptor signaling pathway where BTN3A2 collaborates with BTN3A1 to modulate immune responses. Another significant involvement is in the gamma delta T-cell activation pathway. BTN3A2 partners with proteins like phosphoantigens and other butyrophilins emphasizing its role in controlling T-cell mediated immune functions.\u003cbr\u003e\nBTN3A2 relates to certain autoimmune conditions and cancers. Altered expression of BTN3A2 connects to disorders like psoriasis where dysregulated immune activity plays a part. The protein also connects to chronic lymphocytic leukemia as abnormal BTN3A2 signaling could drive leukemic T-cell behavior. Through these diseases BTN3A2 associates with related proteins such as BTN3A1 and histone deacetylases interacting in pathways disrupted in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845147021481,"sku":"ab265300","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab265300","provider":"Iright","version":"1.0","type":"link"}