{"product_id":"abcam-ab265316","title":"Abcam, ab265316, Human S100A16 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nS100A16 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 2 and 4 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 2 and 4 bp insertion in exon 2,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-S100A16, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nS100A16 also known as S100 calcium-binding protein A16 belongs to the S100 protein family. With a molecular mass of approximately 10.7 kDa S100A16 plays a role in the regulation of calcium homeostasis and cell differentiation. It is expressed in various tissues including the brain heart and adipose tissue. Like other S100 proteins S100A16 possesses two EF-hand motifs which facilitate its ability to bind to calcium ions influencing its structural conformation and function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nS100A16 is involved in cellular processes such as proliferation differentiation and migration. It participates in the modulation of cytoskeletal dynamics and cell cycle regulation. S100A16 often integrates into multiprotein complexes where it interacts with target proteins to exert its biological effects. Studies show that S100A16 may also contribute to epithelial-mesenchymal transition (EMT) an important event in development and cancer progression.\u003cbr\u003e\nPathways\u003cbr\u003e\nS100A16 functions in signaling pathways linked to calcium-dependent processes. In the MAPK signaling pathway it interacts with proteins like ERK1\/2 to regulate cell proliferation and survival. Furthermore S100A16 is also associated with the TGF-beta pathway where its role in EMT becomes significant and involves interactions with TGF-beta-related factors. These pathways underline the importance of S100A16 in cellular homeostasis and developmental processes.\u003cbr\u003e\nS100A16 is implicated in cancer and metabolic disorders. Its overexpression has been observed in several types of cancer including breast and colorectal cancer where it might contribute to tumor progression and metastasis. S100A16 also interacts with proteins like MMPs which are involved in tissue remodeling and invasion. Additionally S100A16 plays a part in metabolic diseases potentially through its role in adipocyte differentiation and lipid metabolism highlighting its multifaceted contribution to human health and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845164060841,"sku":"ab265316","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab265316","provider":"Iright","version":"1.0","type":"link"}