{"product_id":"abcam-ab265444","title":"Abcam, ab265444, Human SMIM4 (C3orf78) knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nUQCC5 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and Insertion of the selection cassette in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and Insertion of the selection cassette in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-UQCC5, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC3orf78 also known as Chromosome 3 Open Reading Frame 78 is a protein with a molecular weight of approximately 80 kDa. This protein exhibits expression in various tissues but data on specific cell types remain limited. Mechanically C3orf78 functions as a protein with potential regulatory roles in cells although detailed molecular mechanisms are still under investigation. Current research suggests interactions with other cellular components hinting at complex roles yet to be fully elucidated.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC3orf78 plays a part in cellular processes that may involve interactions with other proteins as part of a larger complex. Its exact biological role remains under investigation but initial studies suggest it may influence cellular homeostasis and signaling. C3orf78's expression in diverse tissue types implies involvement in multiple physiological functions possibly affecting normal cellular activities through regulatory mechanisms and interactions with yet unidentified partners.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearch has positioned C3orf78 within cellular signaling pathways potentially influencing cellular responses. Its connections in the Ras signaling pathway suggest associations with cell growth and differentiation processes. Also C3orf78 could relate to the PI3K-AKT pathway known to be critical for cell survival. Interactions with related signaling proteins such as KRAS and PI3K might affect these pathways highlighting its potential role in modulating cellular events.\u003cbr\u003e\nMutations or dysregulation of C3orf78 may contribute to the development of cancer and neurological diseases. While direct evidence remains sparse its involvement in cancer is hypothesized through interactions with oncogenes like KRAS. Additionally in neurological contexts abnormal C3orf78 expression may engage with pathways related to proteins like mTOR impacting neurodegenerative processes. Continued research aims to clarify its role in these pathological conditions and validate these initial associations.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845165994153,"sku":"ab265444","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab265444","provider":"Iright","version":"1.0","type":"link"}