{"product_id":"abcam-ab265737","title":"Abcam, ab265737, Human C19orf33 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nIMUP KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and 37 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp insertion in exon 1 and 37 bp insertion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-IMUP, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe IMUP protein also known as C19orf33 has a molecular weight of approximately 17 kDa. This small protein is expressed in various tissues across the human body with noticeable levels in immune-related tissues like the spleen and lymph nodes. The specific cellular localization and expression patterns suggest a role in the immune system's functions. Researchers frequently investigate it to understand its potential interactions and effects better.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIMUP participates in immune system regulation and cellular processes. It does not operate alone but forms part of a protein complex that influences immune responses. This complex is critical in recognizing and responding to foreign antigens aiding the immune system in distinguishing between self and non-self entities. The protein's involvement in cellular signaling pathways indicates its role in managing cell communication and response to environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe IMUP protein plays roles within immune signaling and inflammatory pathways. For example immune response pathways such as the NF-kB pathway involve IMUP as a modulator. Proteins like TNF-alpha interact closely with IMUP influencing its role in signaling processes that regulate inflammation and cellular survival. These interactions highlight its importance in immune response regulation and complex signaling networks.\u003cbr\u003e\nIMUP is associated with autoimmune diseases and chronic inflammatory conditions. Researchers have identified its altered expression in autoimmune disorders such as rheumatoid arthritis where it's implicated in the disease's pathogenesis. It interacts with proteins like IL-6 which are known to contribute to the inflammatory environment characteristic of these conditions. Understanding IMUP's involvement in such diseases may offer insights into potential therapeutic targets and treatment strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845158916265,"sku":"ab265737","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab265737","provider":"Iright","version":"1.0","type":"link"}