{"product_id":"abcam-ab265867","title":"Abcam, ab265867, Human ATG16L2 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nATG16L2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 6. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 6,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ATG16L2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nATG16L2 also known as Autophagy Related 16 Like 2 is a protein that plays a role in the autophagy process. It weighs approximately 80 kDa. Scientists find ATG16L2 in various tissues with notable expression in immune system-related tissues. The protein exhibits structural similarities to ATG16L1 another key autophagy protein and shares a role in the formation of autophagosomes by providing a scaffold for the recruitment of other autophagic proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nATG16L2 contributes to cellular homeostasis by supporting autophagic activity. It associates with the ATG5-ATG12 complex essential for the formation of autophagosomes. This interaction ensures the delivery of cytoplasmic content to lysosomes for degradation an important step in autophagic flux. The presence of ATG16L2 in immune cells suggests an additional role in modulating immune responses and maintaining balance during stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nATG16L2 is primarily involved in the autophagy and lysosomal degradation pathways. These pathways are important for maintaining cell survival under nutrient-deprived conditions. Within its pathways ATG16L2 interacts closely with proteins like LC3 which is necessary for autophagosome maturation and function. It's part of the larger network of proteins orchestrating the cellular response to metabolic stress and damage.\u003cbr\u003e\nAlterations in ATG16L2 expression or function have been linked to certain autoimmune diseases such as Crohn's disease. This connection suggests a role in the modulation of immune function that might affect inflammation. ATG16L2 like its counterpart ATG16L1 shares a relationship with proteins involved in immune regulation highlighting its potential impact on immune-mediated disorders. Understanding the regulation of ATG16L2 could provide insights into therapeutic strategies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845196140713,"sku":"ab265867","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab265867","provider":"Iright","version":"1.0","type":"link"}