{"product_id":"abcam-ab265920","title":"Abcam, ab265920, Human ABCF3 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nABCF3 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 2,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ABCF3, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ABCF3 protein also known as ATP-binding cassette sub-family F member 3 functions in cellular processes involving ATP binding and hydrolysis. This protein weighs approximately 95 kDa. It shows expression in several tissues including the liver kidney and testis. As part of the ATP-binding cassette (ABC) family it lacks a transmembrane domain but participates significantly in nucleotide binding.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nABCF3 plays a role in cellular stress response and protein synthesis regulation. It often forms part of a multi-protein complex aiding the translation process by interacting with ribosomal subunits. This interaction suggests an involvement in the regulation of translation initiation which is important for effective protein synthesis. Additionally ABCF3 may have a role in maintaining cellular homeostasis under stress conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe ABCF3 protein significantly contributes to the mechanistic target of rapamycin (mTOR) signaling pathway and the integrated stress response pathway. Its interaction with ribosomal proteins suggests a regulatory effect on mTOR signaling which is integral to cell growth and metabolism. ABCF3 also indirectly influences other signaling proteins involved in these pathways such as eukaryotic initiation factors which are key translational regulators.\u003cbr\u003e\nStudies show ABCF3's involvement in cancer and inflammatory responses. Aberrant expression of ABCF3 links with tumorigenesis influencing cancer cell proliferation and survival. It connects to other cancer-related proteins including mTOR-related proteins highlighting its role in tumor progression. Additionally involvement in inflammatory pathways suggests connections to inflammation-driven conditions where ABCF3 might affect inflammatory regulators.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845196501161,"sku":"ab265920","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab265920","provider":"Iright","version":"1.0","type":"link"}