{"product_id":"abcam-ab266266","title":"Abcam, ab266266, Human TACC1 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nTACC1 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 19 bp deletion in exon 3 and 8 bp deletion in exon 3. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 19 bp deletion in exon 3 and 8 bp deletion in exon 3\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-TACC1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTACC1 also known as Transforming Acidic Coiled-Coil-Containing Protein 1 is a significant protein with a molecular mass of approximately 80 kDa. This protein primarily interacts in the centrosome and spindle microtubules of cells. TACC1 is an important player in regulating microtubule dynamics during mitosis and is widely expressed in various tissues including the brain liver and testis. The protein structure contains coiled-coil domains important for its function in stabilization and organization of microtubules.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTACC1 engages in processes that contribute to proper cell division and genomic stability. It forms part of a larger molecular complex that includes components like the ch-TOG partner assisting in anchoring and stabilizing microtubules important for mitotic spindle function. TACC1 indirectly affects the balance between cell proliferation and apoptosis showing its importance in maintaining healthy cell cycles. Its role in spindle formation ensures accurate segregation of chromosomes which is critical for preventing aneuploidies.\u003cbr\u003e\nPathways\u003cbr\u003e\nTACC1 is involved in mitotic signaling and microtubule organization pathways. It interacts with Aurora A kinase an essential element of the mitotic entry pathway ensuring that kinetochores are properly attached to spindle microtubules during mitosis. Another pathway involves the PI3K\/AKT signaling where TACC1 may influence cellular responses to growth factors. Its interaction with Aurora A demonstrates the protein's importance in centrosome maturation and spindle stability highlighting its role in cell cycle regulation.\u003cbr\u003e\nTACC1 relates to certain cancers particularly breast and ovarian cancer. Aberrant expression or mutations of TACC1 can lead to disrupted cellular proliferation control and genomic instability. In breast cancer TACC1 often shows altered expression alongside BRCA1 suggesting a direct connection within pathways that govern tumor suppression and DNA repair. Ovarian cancer studies also indicate that changes in TACC1 levels could correlate with tumor aggressiveness positioning it as a potential prognostic marker.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845146595497,"sku":"ab266266","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab266266","provider":"Iright","version":"1.0","type":"link"}