{"product_id":"abcam-ab266550","title":"Abcam, ab266550, Human CHCHD6 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nCHCHD6 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Insertion of the selection cassette in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Insertion of the selection cassette in exon 1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-CHCHD6, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCHCHD6 also known as coiled-coil-helix-coiled-coil-helix domain containing 6 is a protein with a mass of around 31 kDa. This protein is localized in the mitochondria and is expressed across several tissues indicating its broad functional importance in cellular energy metabolism. The protein structure of CHCHD6 includes a characteristic coiled-coil-helix domain which suggests a role in protein-protein interactions potentially contributing to its mechanical functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe coiled-coil-helix domain containing protein 6 is involved in mitochondrial function and maintenance. CHCHD6 participates in the formation of complexes within the inner mitochondrial membrane. These complexes are critical for the proper assembly and stability of mitochondrial respiratory supercomplexes which facilitate efficient electron transport and energy production. This involvement positions CHCHD6 as an important player in maintaining cellular energy dynamics and bioenergetics.\u003cbr\u003e\nPathways\u003cbr\u003e\nCHCHD6 has a role in the mitochondrial electron transport chain which is important for ATP production. This protein associates with pathways governing mitochondrial dynamics and energy metabolism. CHCHD6 interacts with mitochondrial proteins like OPA1 which regulates mitochondrial fusion and cristae morphology contributing to the maintenance of respiratory chain integrity and energy output.\u003cbr\u003e\nThe dysfunction of CHCHD6 can lead to altered mitochondrial homeostasis contributing to conditions such as mitochondrial disorders and neurodegenerative diseases like Alzheimer's disease. It is associated with proteins such as the mitochondrial cytochrome C oxidase which also play a role in bioenergetic processes and can influence the pathogenesis of these diseases. Understanding CHCHD6 interactions and functions could provide insights into potential therapeutic targets for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845163471017,"sku":"ab266550","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab266550","provider":"Iright","version":"1.0","type":"link"}