{"product_id":"abcam-ab266553","title":"Abcam, ab266553, Human NDUFV1 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nNDUFV1 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-NDUFV1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNDUFV1 also known as NADH-ubiquinone oxidoreductase 51 kDa subunit plays a mechanical role in the electron transport chain. It has a molecular mass of approximately 51 kDa. The protein is an integral part of Complex I or NADH:ubiquinone oxidoreductase located in the inner mitochondrial membrane. NDUFV1 shows expression across various tissues with higher levels found in metabolically active tissues like skeletal muscle and heart.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNDUFV1 participates in oxidative phosphorylation within cells. This protein functions as a core subunit of Complex I which is the first enzyme in the mitochondrial respiratory chain. NDUFV1 has a role in transferring electrons from NADH to ubiquinone an essential step for energy production. The efficient operation of Complex I affects ATP synthesis which is necessary for many cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nNDUFV1 is central to the energy production in mitochondria. It is important for the oxidative phosphorylation pathway and is involved in maintaining the proton gradient across the inner mitochondrial membrane. This protein closely interacts with other subunits of Complex I like NDUFS1 and has significant synergy with them in electron transfer processes. Its activity is indispensable for proper cellular respiration and energy metabolism.\u003cbr\u003e\nNDUFV1 mutations link to mitochondrial diseases such as Leigh syndrome and some cases of Complex I deficiency. In patients with these conditions there are disruptions in ATP production due to impaired electron transport chain function. The protein may also be involved in some forms of neurodegenerative diseases where mitochondrial dysfunction plays a role. NDUFS1 and other Complex I subunits often show associations with these disorders highlighting the importance of NDUFV1 in neuromuscular and metabolic health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845208920233,"sku":"ab266553","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab266553","provider":"Iright","version":"1.0","type":"link"}