{"product_id":"abcam-ab266564","title":"Abcam, ab266564, Human RAB2A (Rab2) knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nRAB2A KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp deletion in exon 1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-RAB2A, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRab2 also known as Ras-related protein Rab-2 is a small GTPase with a mass of approximately 24 kDa. It belongs to the Rab family of proteins which are key regulators of intracellular membrane trafficking. Rab2 plays a critical role in vesicle transport between the endoplasmic reticulum (ER) and the Golgi apparatus. It is widely expressed in various tissues with significant presence in brain and liver tissues. This expression pattern indicates its involvement in essential cellular processes across different cell types.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRas-related protein Rab-2 mediates the trafficking of proteins and lipids within the secretory pathway. Rab2 associates with the cytosolic face of membranes aiding in the formation and movement of vesicles. It forms part of a complex that regulates tethering and docking facilitating vesicle fusion. Rab2 interaction with its effectors ensures accurate delivery of cargo to the correct cellular compartments. This functionality supports the maintenance of cellular organization and communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nRas-related protein Rab-2 functions in the ER-Golgi transport pathway and the autophagy pathway. In the ER-Golgi transport pathway it interacts with proteins such as Golgi SNAREs to enhance vesicle sorting and fusion. Rab2 also has connections with the autophagy-related proteins where it supports the formation of autophagosomes therefore contributing to cellular homeostasis and turnover. Its activity impacts the coordination between membrane trafficking and recycling processes within cells.\u003cbr\u003e\nRas-related protein Rab-2 has relevance to neurodegenerative conditions and cancer. Abnormal Rab2 expression or function associates with Alzheimer's disease where its dysregulation affects ER-Golgi transport and protein processing. Additionally Rab2 involvement in cancer relates to its role in protein trafficking and cellular growth interacting with proteins like Ras and RalA within signaling cascades. These interactions highlight the importance of Rab2 in the pathology and progression of these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845195387049,"sku":"ab266564","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab266564","provider":"Iright","version":"1.0","type":"link"}