{"product_id":"abcam-ab266594","title":"Abcam, ab266594, Human COX8A knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nCOX8A KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-COX8A, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCOX8A also known as Cytochrome c oxidase subunit 8A is a component of the cytochrome c oxidase complex which plays a vital role in the electron transport chain within mitochondria. This protein has a molecular mass of approximately 8.7 kDa. COX8A is highly expressed in tissues with high energy demands such as muscle and brain where efficient ATP production is needed.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCOX8A is an integral part of the large cytochrome c oxidase complex also known as Complex IV in the mitochondrial inner membrane. This complex is involved in oxidative phosphorylation where it catalyzes the reduction of oxygen to water a final step of the electron transport chain. COX8A contributes to the correct assembly and stability of the cytochrome c oxidase complex ensuring proper mitochondrial function and energy production.\u003cbr\u003e\nPathways\u003cbr\u003e\nCOX8A participates in the oxidative phosphorylation pathway and is an important player in the process that produces ATP from ADP and inorganic phosphate. It functions together with other subunits in Complex IV such as COX2 and COX3 to facilitate efficient electron transfer and proton pumping. Through its activity in these processes COX8A directly influences cellular respiration and energy metabolism which are critical for cellular homeostasis.\u003cbr\u003e\nCOX8A has connections to mitochondrial disorders such as Leigh syndrome and cytochrome c oxidase deficiency. These conditions arise from defects in mitochondrial oxidative phosphorylation affecting tissues with high metabolic demands. Alterations in COX8A along with other complex IV components like COX2 can contribute to the pathogenesis of these diseases as they disrupt ATP production and lead to energy deficits in affected cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845211312297,"sku":"ab266594","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab266594","provider":"Iright","version":"1.0","type":"link"}