{"product_id":"abcam-ab266644","title":"Abcam, ab266644, Human TBRG4 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nTBRG4 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 2\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-TBRG4, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTBRG4 also known as FAM195A or BRG1-Associated Factor-53A is a protein with a molecular mass of approximately 144 kDa. It participates in the regulation of cellular homeostasis and function by interacting with other proteins in the cell. Expression of TBRG4 is not limited to a specific tissue as it can be detected in multiple tissues across the body including brain and immune cells. Due to its versatile expression TBRG4 likely takes part in general cellular mechanisms across different cell types.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTBRG4 influences several cellular processes through its involvement in protein interactions. It is an integral part of large molecular complexes that regulate various gene expression and remodeling of chromatin. TBRG4 often functions in concert with other components to ensure accurate modulation of transcriptional activity. Complex formation affects both direct regulation of target genes and the structural rearrangements necessary for cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe protein plays a role in the cellular response to stress and metabolic signaling. It acts within the mTOR signaling pathway which is central to the regulation of growth and metabolism. TBRG4 interacts with other proteins like Raptor and mLST8 to modulate mTOR complex functions. Additionally it is related to the PKC signaling pathway where it may indirectly influence cellular responses to external stimuli through modulation of other participating proteins.\u003cbr\u003e\nTBRG4 connects to both cancer and neurodegenerative diseases due to its role in cell growth and stress response. Abnormal expression or malfunction of TBRG4 may contribute to the progression of certain cancers reflecting its interaction with proteins like p53 in tumor suppression pathways. In neurodegenerative conditions alterations in TBRG4-related pathways might exacerbate pathological features particularly through dysregulated signaling mechanisms involving proteins such as Tau.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845211541673,"sku":"ab266644","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab266644","provider":"Iright","version":"1.0","type":"link"}