{"product_id":"abcam-ab266803","title":"Abcam, ab266803, Human NPTN knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nNPTN KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 5 bp deletion in exon 3 and 8 bp deletion in exon 3. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 5 bp deletion in exon 3 and 8 bp deletion in exon 3\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-NPTN, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeuroplastin (NPTN) also known as Basigin-like protein 1 plays an important role in various cellular functions. This protein has a mass of approximately 34 kDa as determined by its amino acid sequence. NPTN locates itself on the cell membrane and exhibits expression in multiple tissues especially in the nervous system and skeletal muscles. This protein is known for participating actively in cell adhesion processes which influence neural development and synaptic plasticity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeuroplastin contributes to important cellular processes like calcium homeostasis and synapse formation. As part of the oligomeric receptor complex it facilitates calcium-mediated signaling by forming functional partnerships with other membrane proteins such as plasma membrane Ca2+ ATPases. Neuroplastin's interactions influence dendritic spine morphology and synaptic strength which are essential for proper neuronal communication and memory formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuroplastin functions significantly in the Calcium signaling pathway which regulates numerous cellular activities including muscle contraction and neurotransmitter release. It associates with proteins like PMCA playing a role in calcium ion efflux and maintaining intracellular calcium concentration. Additionally Neuroplastin is involved in the MAP kinase signaling pathway which contributes to cell viability and adaptation to stress.\u003cbr\u003e\nNeuroplastin shows linkage to conditions such as schizophrenia and hearing loss. Abnormal expression or mutations of NPTN can disrupt neural connectivity and synaptic functions potentially leading to psychiatric disorders. Furthermore studies associate NPTN with Basigin in disorders affecting auditory capacities suggesting possible therapeutic targets for intervention in inner ear function deficits.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845147742377,"sku":"ab266803","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab266803","provider":"Iright","version":"1.0","type":"link"}