{"product_id":"abcam-ab267190","title":"Abcam, ab267190, Human GBP3 knockout A549 cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nGBP3 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 3 and 1 bp insertion in exon 3. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:A549,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Lung,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 3 and 1 bp insertion in exon 3,\u003cbr\u003e\nDisease:Carcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-GBP3, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein known as GBP3 also called Guanylate Binding Protein 3 is a member of the guanylate-binding protein family. This protein has a molecular mass of approximately 67 kDa. It mainly functions in cellular processes involving GTP hydrolysis which plays a significant role in certain immune responses. GBP3 expresses in various tissues including the heart placenta and lungs showing higher presence in immune-related cells and tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGBP3 contributes to cellular defense by promoting anti-viral states and mediating immune signaling. It has been found to associate with large protein complexes that enhance its stability and activity during inflammation. This involvement supports various immune functions and contributes to the body's response to pathogenic threats. Such actions highlight GBP3's importance in maintaining cellular immunity and promoting pathogenic resistance.\u003cbr\u003e\nPathways\u003cbr\u003e\nGBP3 interacts within the interferon-gamma signaling pathway where it facilitates host defense mechanisms. The protein's activity aligns closely with the JAK-STAT pathway important for the transduction of extracellular signals from the environment to the cell nucleus. GBP3 operates alongside other proteins such as GBP1 and GBP5 which are also part of guanylate-binding proteins involved in immune regulation and protection against intracellular bacteria and viruses.\u003cbr\u003e\nImpairments in GBP3 function have connections to infectious diseases and inflammatory disorders. Studies suggest that altered GBP3 expression might relate to an increased susceptibility to viral infections such as hepatitis. Additionally abnormalities in this protein may associate with chronic inflammatory conditions like Crohn's disease. GBP3 interacts with proteins like STAT1 and GBP1 which play critical roles in modulating immune response and maintaining homeostasis within inflammatory conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845146529961,"sku":"ab267190","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab267190","provider":"Iright","version":"1.0","type":"link"}