{"product_id":"abcam-ab269101","title":"Abcam, ab269101, Recombinant human Ube2G1 protein (Active)","description":"\u003cp\u003eSize: 20µg\u003cbr\u003e\nRecombinant human Ube2G1 protein (Active) is a Human Full Length protein, expressed in Escherichia coli, with \u0026gt;95%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% SDS-PAGE,\u003cbr\u003e\nExpression system:Escherichia coli,\u003cbr\u003e\nTags:His tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab269101 was 11 nmol\/min\/mg in a ubiquitinating assay using wild-type ubiquitin as substrate.,\u003cbr\u003e\nAccession:P62253,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7Preservative: 1.02% ImidazoleConstituents: 25% Glycerol (glycerin, glycerine), 1.74% Sodium chloride, 0.82% Sodium phosphate, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUbe2G1 also known as ubiquitin-conjugating enzyme E2 G1 plays an important role in the ubiquitination process. This protein with a molecular mass of about 23 kDa is involved in tagging substrates with ubiquitin for proteasomal degradation—an important cellular mechanism that regulates protein levels and quality. Ube2G1 expresses in various tissues including the liver and central nervous system highlighting its broad role in maintaining cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUbe2G1's primary function supports protein homeostasis and cellular stress responses. It collaborates with E3 ubiquitin ligases in a complex to mediate the transfer of ubiquitin molecules to their targets. This activity is essential in controlling various cellular processes such as cell cycle regulation DNA repair and signal transduction. By participating in these functions Ube2G1 assures that the cellular environment remains stable and efficient.\u003cbr\u003e\nPathways\u003cbr\u003e\nUbe2G1 has pivotal involvement in the ubiquitin-proteasome pathway which is significant for the regulated degradation of misfolded or damaged proteins. Additionally it interacts with components of the endoplasmic reticulum-associated degradation (ERAD) pathway working alongside proteins like Derlin-1 to eliminate faulty proteins from the ER. Through these pathways Ube2G1 contributes to cellular health by preventing protein aggregation and dysfunction.\u003cbr\u003e\nImproper function of Ube2G1 can have serious implications for neurological conditions such as Alzheimer's disease due to the accumulation of misfolded proteins. Additionally cancer progression is linked to disruptions in protein degradation mechanisms involving Ube2G1 as it influences cell cycle and apoptosis. In cancer Ube2G1 can interact with tumor suppressor proteins like p53 affecting their stability and activity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843982151849,"sku":"ab269101","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab269101","provider":"Iright","version":"1.0","type":"link"}