{"product_id":"abcam-ab269875","title":"Abcam, ab269875, BMS-833923, smoothened antagonist","description":"\u003cp\u003eSize: 5mg \/ 10mg \/ 50mg\u003cbr\u003e\nMW 473.6 Da. Potent Smoothened antagonist (IC 50  = 5.8 nM). Blocks Hedgehog signaling in cell-based assays. Inhibits Gli1 and PTCH1 expression in cell lines. Reduces proliferation and induces apoptosis in tumor cellls.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1059734-66-5,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:473.6 Da,\u003cbr\u003e\nMolecular formula:C30H27N5O,\u003cbr\u003e\nPubChem:57662985,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 5 mMSoluble in DMSO to 100 mMSoluble in ethanol to 10 mM (with warming and ultrasonic),\u003cbr\u003e\nBiochemical name:N-(2-Methyl-5-((methylamino)methyl)phenyl)-4-((4-phenylquinazolin-2-yl)amino)benzamide,\u003cbr\u003e\nBiological description:Potent Smoothened antagonist (IC50 = 5.8 nM). Blocks Hedgehog signaling in cell-based assays. Inhibits Gli1 and PTCH1 expression in cell lines. Reduces proliferation and induces apoptosis in tumor cellls.,\u003cbr\u003e\nCanonical smiles:CC1=C(C=C(C=C1)CNC)NC(=O)C2=CC=C(C=C2)NC3=NC4=CC=CC=C4C(=N3)C5=CC=CC=C5,\u003cbr\u003e\nInChi:InChI=1S\/C30H27N5O\/c1-20-12-13-21(19-31-2)18-27(20)33-29(36)23-14-16-24(17-15-23)32-30-34-26-11-7-6-10-25(26)28(35-30)22-8-4-3-5-9-22\/h3-18,31H,19H2,1-2H3,(H,33,36)(H,32,34,35),\u003cbr\u003e\nInChiKey:KLRRGBHZCJLIEL-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-[2-methyl-5-(methylaminomethyl)phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847478366377,"sku":"ab269875","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab269875","provider":"Iright","version":"1.0","type":"link"}