{"product_id":"abcam-ab269958","title":"Abcam, ab269958, Anti-DHX36 antibody [EPR20868-12] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DHX36 antibody. Carrier free. Suitable for IP, WB and reacts with Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR20868-12,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab269958 is the carrier-free version of\u003cbr\u003e\nab223564\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDHX36 also known as RHAU or G4R1 is a member of the DEAH-box family of RNA helicases. It has an estimated molecular mass of approximately 115 kDa. The protein exhibits robust expression in various tissues including the heart skeletal muscle and brain. Mechanically DHX36 plays a role in resolving RNA G-quadruplexes and DNA G-quadruplexes which are secondary structures that can form in nucleic acids. Its ability to unwind these structures is critical for the regulation of gene expression and maintenance of genomic stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDHX36 acts as an RNA helicase and is essential in the regulation of translation and transcription. It plays a significant role in binding G-quadruplex structures within the 5' untranslated region of mRNAs. DHX36 also forms part of larger protein complexes that regulate ribosome assembly and function. This protein helps ensure proper ribosomal RNA processing facilitating efficient protein synthesis. Through its involvement in these complexes DHX36 aids in the regulation of cellular stress responses and apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nDHX36 significantly contributes to several cellular processes notably the regulation of transcription and translation. It actively participates in the Wnt signaling pathway influencing the stability of target mRNAs. DHX36 also interacts with proteins like FTO and NPM1 that are known to be involved in mRNA processing. These interactions and pathway linkages highlight its role in controlling gene expression and cellular growth.\u003cbr\u003e\nDHX36 has been linked to cardiac dysfunctions and neurological disorders. Its improper functioning has been associated with arrhythmias due to its role in cardiac gene expression regulation. In neurological contexts DHX36 disruptions may contribute to various cognitive disorders acting through its impact on synaptic protein synthesis. In these pathological conditions proteins such as TDP-43 and FUS are affected emphasizing the importance of DHX36 in maintaining cellular homeostasis and preventing disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851932782761,"sku":"ab269958","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab269958","provider":"Iright","version":"1.0","type":"link"}