{"product_id":"abcam-ab270326","title":"Abcam, ab270326, Anti-Dscam antibody [EPR22435-265] - BSA and Azide free (Capture)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal DSCAM antibody. Carrier free. Suitable for sELISA and reacts with Mouse, Rat, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22435-265,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Rat, Mouse,\u003cbr\u003e\nApplications:sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab270326 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify DSCAM. The recommended pair for sandwich ELISA is:\u003cbr\u003e\nCapture: ab270326, DSCAM Capture Antibody (unconjugated)\u003cbr\u003e\nDetector:\u003cbr\u003e\nab270327\u003cbr\u003e\n, DSCAM Detector Antibody (unconjugated)\u003cbr\u003e\nThe reference range value is 203.125 - 13000 pg\/ml.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nSandwich ELISA\u003cbr\u003e\nThe recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDscam known as Down Syndrome Cell Adhesion Molecule is a protein with a mass of around 230 kDa. It functions as a cell adhesion molecule and is involved in axon guidance. Dscam is expressed in various tissues with high levels in the nervous system particularly during developmental stages. The protein plays a role in neural development by ensuring proper neuronal connections.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDscam contributes to neuronal differentiation and synaptic targeting. It belongs to the immunoglobulin superfamily and is involved in forming non-covalent complexes with other cell adhesion molecules. The protein facilitates homophilic binding which regulates axonal and dendritic branching. This process ensures neural circuits form correctly impacting brain development and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nDscam participates in the neural development pathway which includes interactions with the Robo receptor affecting axonal migration and guidance. The protein also links to the slit-Robo pathway playing a substantial role in neural patterning. These interactions ensure the precise wiring required for functional neural networks influencing how neural signals propagate.\u003cbr\u003e\nDscam's dysregulation connects to neurological conditions like Down syndrome and autism spectrum disorders. It interacts with proteins involved in these disorders like the ROBO proteins which mediate axon guidance. Accumulating evidence suggests that altered Dscam expression impairs neuronal connectivity contributing to the pathophysiology of these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852532928681,"sku":"ab270326","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab270326","provider":"Iright","version":"1.0","type":"link"}