{"product_id":"abcam-ab270757","title":"Abcam, ab270757, Anti-SEC23B + SEC23A antibody [EPR22723-102] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal SEC23B antibody. Carrier free. Suitable for IHC-P, WB and reacts with Mouse, Rat, Human, Recombinant full length protein - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22723-102,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab270757 is the carrier-free version of\u003cbr\u003e\nab270750\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSEC23B and SEC23A are proteins involved in the formation of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus. These proteins are part of the COPII coat protein complex. SEC23B has a mass of approximately 92 kDa while SEC23A is about 88 kDa. Both proteins are widely expressed with significant levels in the liver pancreas and other tissues. SEC23B and SEC23A share high sequence homology reflecting similar roles within cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSEC23B and SEC23A are key components of the COPII complex working together with SEC24 SEC13 and SEC31 to facilitate the budding of vesicles from the ER. This complex regulates cargo selection and vesicle budding ensuring correct protein transport. Both proteins interact closely with SAR1 a small GTPase that initiates COPII coat assembly. The functionality of SEC23B and SEC23A is significant in maintaining cellular homeostasis by ensuring the efficient transport of proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nSEC23B and SEC23A are integral in the secretory pathway a fundamental process in cell biology. The secretory pathway involves the transport of newly synthesized proteins from the ER to the Golgi and ultimately to their final destinations. Within this pathway SEC23B and SEC23A work alongside SEC24 to select cargo proteins that need transport. Their activities are connected to the vesicular transport pathway emphasizing the interplay with SAR1 and other COPII components.\u003cbr\u003e\nSEC23B mutations are linked to Congenital Dyserythropoietic Anemia type II (CDAII) which affects red blood cell production and function. This disorder highlights SEC23B’s role in erythroid cell development. Moreover SEC23A mutations are associated with cranio-lenticulo-sutural dysplasia a rare disease impacting craniofacial and skeletal development. The involvement of SEC23B and SEC23A in these disorders indicates their essential roles in specialized cell processes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852370268329,"sku":"ab270757","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab270757","provider":"Iright","version":"1.0","type":"link"}