{"product_id":"abcam-ab270998","title":"Abcam, ab270998, Anti-ProCathepsin B antibody [EPR24353-25]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Cathepsin B antibody. Suitable for Flow Cyt (Intra), WB, IHC-P and reacts with Mouse, Human, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24353-25,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Human, Rat,\u003cbr\u003e\nApplications:WB, IHC-P, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProCathepsin B also known as Cathepsin B precursor or CTSB is a cysteine protease with a mature form mass of around 37 kDa. This protein begins as an inactive zymogen requiring processing to become active. It expresses mainly in lysosomes but can also be found extracellularly particularly in disease states. Typically abundant in various tissues ProCathepsin B undergoes proteolytic activation by removal of its propeptide region to function effectively in proteolysis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProCathepsin B facilitates protein catabolism by degrading extracellular matrix components. It does not commonly form part of a larger protein complex allowing it to perform its proteolytic activity independently. The protein's actions are important for cellular turnover and tissue remodeling. In healthy tissues ProCathepsin B supports normal cellular homeostasis but dysregulation can lead to pathological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nProCathepsin B plays a role in the proteolytic pathways involving processes such as autophagy and apoptosis. It participates in the ubiquitin-proteasome pathway interrelated with proteins like Ubiquitin and Caspases. These pathways control protein degradation and programmed cell death highlighting ProCathepsin B's importance in maintaining cellular function and regulation.\u003cbr\u003e\nProCathepsin B is associated with conditions like cancer and arthritis. In cancer its overexpression facilitates tumor invasion and metastasis often linked with proteins such as Matrix Metalloproteinases (MMPs). In arthritis increased ProCathepsin B activity contributes to joint tissue breakdown connecting with Collagen too. These associations make ProCathepsin B a potential target for therapeutic intervention in such disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850196570281,"sku":"ab270998","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab270998","provider":"Iright","version":"1.0","type":"link"}