{"product_id":"abcam-ab272618","title":"Abcam, ab272618, Anti-FANCL antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal FANCL antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human FANCL aa 50-200.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human FANCL aa 50-200. The exact immunogen used to generate this antibody is proprietary information.Q9NW38\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFANCL also known as Fanconi anemia group L protein participates in the Fanconi anemia (FA) pathway. It has a molecular mass of about 42 kDa. FANCL expresses in various tissues with notable expression in the bone marrow and blood-forming organs. The protein works mechanically by functioning as an E3 ubiquitin ligase essential for monoubiquitination of FANCD2 and FANCI which is an important step in the FA DNA repair pathway.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays a role in DNA damage repair. FANCL is part of a multiprotein FA complex which is responsible for the repair of DNA interstrand crosslinks. The FA complex coordinates the activation and repair processes required to maintain genome stability. It ensures proper cell cycle progression while responding to DNA damage facilitating normal cellular function and development.\u003cbr\u003e\nPathways\u003cbr\u003e\nFANCL is a component of the FA-BRCA pathway and has strong connections with DNA repair processes. This pathway includes interactions with proteins such as BRCA1 and BRCA2 which manage DNA repair to prevent tumorigenesis. FANCL also engages with elements of the homologous recombination repair pathway where it ensures proper DNA repair by managing the ubiquitination processes.\u003cbr\u003e\nDefects in FANCL relate to Fanconi anemia a genetic disorder marked by bone marrow failure and cancer predisposition. The protein's association with BRCA2 also links to hereditary breast and ovarian cancers. These connections highlight FANCL's significance in maintaining genetic integrity and its potential impact on cancer development when impaired.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854091833513,"sku":"ab272618","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab272618","provider":"Iright","version":"1.0","type":"link"}