{"product_id":"abcam-ab272634","title":"Abcam, ab272634, Anti-CPSF7 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal CPSF7 antibody. Suitable for IHC-P, WB, ICC\/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPSF7 aa 1-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:ICC\/IF, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CPSF7 aa 1-150. The exact immunogen used to generate this antibody is proprietary information.Q8N684\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCPSF7 also known as cleavage and polyadenylation specificity factor subunit 7 is a protein that participates in mRNA processing. With a mass of approximately 55 kDa CPSF7 resides in the nucleus of cells where it plays a role in the cleavage and polyadenylation of pre-mRNA. This protein is expressed in various tissues emphasizing its broad role in gene expression regulation across different cell types.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCPSF7 functions in the formation of the cleavage and polyadenylation complex which is essential for proper mRNA maturation. It interacts with other subunits in this complex to ensure accurate mRNA 3' end processing. This protein participates in determining the polyadenylation site a critical step that influences mRNA stability export and translation.\u003cbr\u003e\nPathways\u003cbr\u003e\nCPSF7 integrates into the post-transcriptional regulation of gene expression. It plays important roles within the mRNA processing pathway and is linked to the regulation of the cell cycle. CPSF7 interacts with other proteins such as CPSF3 within these pathways to mediate these biological processes that are pivotal for efficient gene expression and cell function.\u003cbr\u003e\nAberrations in CPSF7 function relate to cancer and autoimmune diseases. In cancer altered expression of CPSF7 may affect tumor growth and progression potentially through interactions with other proteins like CPSF73. Autoimmune diseases could also involve CPSF7 due to disruptions in mRNA processing which might affect immune cell function and regulation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854185615529,"sku":"ab272634","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab272634","provider":"Iright","version":"1.0","type":"link"}