{"product_id":"abcam-ab273382","title":"Abcam, ab273382, URMC-099","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 421.5 Da, Purity \u0026gt;98%. Novel orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor (IC 50  values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively). Inhibits multiple kinase pathways including LRRK2 (IC 50  = 11 nM). Decreases the production of inflammatory cytokines in cultured microglia exposed to HIV-1 Tat. Reduces fMLP-induced chemotaxis of neutrophil from wild-type C57Bl\/6 mice. Facilitates Amyloid-β Clearance in a Murine Model of Alzheimer's Disease.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1229582-33-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:421.5 Da,\u003cbr\u003e\nMolecular formula:C27H27N5,\u003cbr\u003e\nPubChem:54764565,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine,\u003cbr\u003e\nBiological description:Novel orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor (IC50 values of 19, 42, 14, and 150 nM for MLK1, MLK2, MLK3, and the related MLK family member DLK, respectively). Inhibits multiple kinase pathways including LRRK2 (IC50 = 11 nM). Decreases the production of inflammatory cytokines in cultured microglia exposed to HIV-1 Tat. Reduces fMLP-induced chemotaxis of neutrophil from wild-type C57Bl\/6 mice. Facilitates Amyloid-β Clearance in a Murine Model of Alzheimer's Disease.,\u003cbr\u003e\nCanonical smiles:CN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(NC=C4C5=CC6=C(C=C5)NC=C6)N=C3,\u003cbr\u003e\nInChi:InChI=1S\/C27H27N5\/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26\/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30),\u003cbr\u003e\nInChiKey:QKKIWEILHCXECO-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847453888681,"sku":"ab273382","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab273382","provider":"Iright","version":"1.0","type":"link"}