{"product_id":"abcam-ab273384","title":"Abcam, ab273384, Buparlisib (BKM120)","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 410.4 Da, Purity \u0026gt;95%. Potent class I PI3K inhibitor, blocking both p110α and p110β (IC₅₀ = 52 nM and 166 nM, respectively)  in vitro . At 5 μM, prevents the growth of assorted cancer cell lines and inhibits tumor growth  in vivo . Reduced effect against class III PI3K Vps34 and mammalian target of rapamycin (mTOR).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:944396-07-0,\u003cbr\u003e\nPurity:\u0026gt;95%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:410.4 Da,\u003cbr\u003e\nMolecular formula:C18H21F3N6O2,\u003cbr\u003e\nPubChem:16654980,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 25 mMSoluble in ethanol to 25 mM,\u003cbr\u003e\nBiochemical name:Buparlisib,\u003cbr\u003e\nBiological description:Potent class I PI3K inhibitor, blocking both p110α and p110β (IC₅₀ = 52 nM and 166 nM, respectively) in vitro. At 5 μM, prevents the growth of assorted cancer cell lines and inhibits tumor growth in vivo. Reduced effect against class III PI3K Vps34 and mammalian target of rapamycin (mTOR).,\u003cbr\u003e\nCanonical smiles:C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4,\u003cbr\u003e\nInChi:InChI=1S\/C18H21F3N6O2\/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27\/h9-11H,1-8H2,(H2,22,23),\u003cbr\u003e\nInChiKey:CWHUFRVAEUJCEF-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:5-(2,6-dimorpholin-4-ylpyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2619 NVP-BKM120. 2619-25 is the same size as the 25 mg size of ab273384.\u003cbr\u003e\nProtect from air.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-It is important to note that this is air sensitive and impurities can occur as a result of air oxidation, Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847473516713,"sku":"ab273384","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab273384","provider":"Iright","version":"1.0","type":"link"}