{"product_id":"abcam-ab273391","title":"Abcam, ab273391, Linsitinib (OSI-906)","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 421.5 Da, Purity 98%. Potent and selective dual IGF-1R (IC 50  = 35 nM in cell-free assay) and Insulin Receptor (IC 50  = 75 nM in cell-free assay) kinase inhibitor. Inactive towards Abl, ALK, BTK, EGFR, FGFR1\/2 and PKA. Displayed \u0026lt;50% inhibition at 1 μM against a panel of 88 kinases. Blocks IGF-1R autophosphorylation and downstream activation of Akt, ERK1\/2 and S6 kinase. Blocks tumor cell line proliferation. Blocks IGF-1R driven tumor xenograft growth.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:867160-71-2,\u003cbr\u003e\nPurity:98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:421.5 Da,\u003cbr\u003e\nMolecular formula:C26H23N5O,\u003cbr\u003e\nPubChem:11640390,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:Linsitinib,\u003cbr\u003e\nBiological description:Potent and selective dual IGF-1R (IC50 = 35 nM in cell-free assay) and Insulin Receptor (IC50 = 75 nM in cell-free assay) kinase inhibitor. Inactive towards Abl, ALK, BTK, EGFR, FGFR1\/2 and PKA. Displayed \u0026lt;50% inhibition at 1 μM against a panel of 88 kinases. Blocks IGF-1R autophosphorylation and downstream activation of Akt, ERK1\/2 and S6 kinase. Blocks tumor cell line proliferation. Blocks IGF-1R driven tumor xenograft growth.,\u003cbr\u003e\nCanonical smiles:CC1(CC(C1)C2=NC(=C3N2C=CN=C3N)C4=CC5=C(C=C4)C=CC(=N5)C6=CC=CC=C6)O,\u003cbr\u003e\nInChi:InChI=1S\/C26H23N5O\/c1-26(32)14-19(15-26)25-30-22(23-24(27)28-11-12-31(23)25)18-8-7-17-9-10-20(29-21(17)13-18)16-5-3-2-4-6-16\/h2-13,19,32H,14-15H2,1H3,(H2,27,28),\u003cbr\u003e\nInChiKey:PKCDDUHJAFVJJB-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:3-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847459131561,"sku":"ab273391","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab273391","provider":"Iright","version":"1.0","type":"link"}