{"product_id":"abcam-ab273523","title":"Abcam, ab273523, PF-573228","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 491.5 Da, Purity \u0026gt;98%. Potent and selective FAK inhibitor (IC 50  = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC 50  = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:869288-64-2,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:491.5 Da,\u003cbr\u003e\nMolecular formula:C22H20F3N5O3S,\u003cbr\u003e\nPubChem:11612883,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 75 mM,\u003cbr\u003e\nBiochemical name:3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone,\u003cbr\u003e\nBiological description:Potent and selective FAK inhibitor (IC50 = 4 nM versus recombunant catalytic fragent). Blocks FAK Tyr397 phosphorylation in cultured cells (IC50 = 30–100 nM). Shows 50 - 250-fold selectivity for FAK aginst a panel of 40 recombinant kinases. Inhibits chemotactic and haptotactic cell migration.,\u003cbr\u003e\nCanonical smiles:CS(=O)(=O)C1=CC=CC(=C1)CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)CC4,\u003cbr\u003e\nInChi:InChI=1S\/C22H20F3N5O3S\/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18\/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30),\u003cbr\u003e\nInChiKey:HESLKTSGTIBHJU-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2819 PF-573228. 2819-50 is the same size as the 50 mg size of ab273523.\u003cbr\u003e\nProtect from air.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847490425001,"sku":"ab273523","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab273523","provider":"Iright","version":"1.0","type":"link"}