{"product_id":"abcam-ab273646","title":"Abcam, ab273646, Anti-Tristetraprolin\/TTP antibody [OTI8B5] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal Tristetraprolin\/TTP antibody. Carrier free. Suitable for IHC-P, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Dog, African green monkey, Transfected cell lysate - Human, Transfected cell line - Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZFP36.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:OTI8B5,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Dog, Human, African green monkey,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human ZFP36.P26651\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab273646 is the carrier-free version of\u003cbr\u003e\nab124024\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Storage buffer-pH: 7.3Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTristetraprolin (TTP) also called ZFP36 is a protein that regulates mRNA stability and decay. It has a molecular mass of approximately 36 kDa. TTP usually resides in the cytoplasm and nucleus of a cell. Many types of tissues especially those involved in immune response express TTP. Researchers have identified TTP as part of a family of CCCH zinc-finger proteins which play key roles in mRNA turnover by binding to AU-rich elements in the 3' untranslated regions of target mRNAs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTTP controls the degradation of cytokine mRNAs such as TNF-alpha and GM-CSF by inducing deadenylation and subsequent decay. As part of mRNA degradation complexes TTP recruits enzymes that participate in the deadenylation process ensuring precise regulation of gene expression. This ability to selectively regulate mRNA levels helps balance the production of proteins important for inflammation immune responses and cell growth. Through these processes TTP maintains cellular homeostasis and modulates responses to environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nTTP functions within the anti-inflammatory pathway by modulating cytokine levels and the NF-kappaB signaling pathway which are important for cellular stress responses and immune regulation. It affects these pathways by interacting with several proteins including 14-3-3 that regulate its activity and localization. Another key interaction is with deadenylase complexes like CAF1 which are integral in carrying out mRNA decay. These interactions allow TTP to effectively manage inflammatory responses reinforcing its regulatory role in immune system pathways.\u003cbr\u003e\nAltered TTP expression or function links to autoimmune diseases and certain cancers. In autoimmune conditions like rheumatoid arthritis reduced TTP levels are associated with an overproduction of inflammatory cytokines. This imbalance leads to chronic inflammation and tissue damage. In cancers especially breast cancer TTP downregulation can contribute to tumor progression by allowing increased expression of mRNAs involved in cell proliferation and survival. Other proteins such as TNF-alpha and IL-6 have been observed to interact closely with TTP in these disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854508413097,"sku":"ab273646","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab273646","provider":"Iright","version":"1.0","type":"link"}