{"product_id":"abcam-ab274328","title":"Abcam, ab274328, Anti-Iroquois homeobox protein 3\/IRX3 antibody [EPR22709-52] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Iroquois homeobox protein 3\/IRX3 antibody. Carrier free. Suitable for WB, IHC-P, Flow Cyt (Intra), ICC\/IF and reacts with Mouse, Rat, Transfected cell line - Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22709-52,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, ICC\/IF, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab274328 is the carrier-free version of\u003cbr\u003e\nab242133\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIroquois homeobox protein 3 also known as IRX3 is a transcription factor that plays a role in gene expression regulation. IRX3 weighs approximately 57 kDa. It is expressed in various tissues prominently in the brain heart and skeletal muscle. IRX3 participates in a network of transcription factors that regulates developmental processes and cellular differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIRX3 serves an important role in the regulation of embryonic pattern formation. It is a part of the Iroquois homeobox gene family which is involved in the development of distinct anatomical regions during embryogenesis. IRX3 assists in determining body structure and organ formation and forms part of transcriptional complexes that guide the spatial organization of tissues. This protein also interacts with other homeobox proteins to accomplish its roles in development and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nIRX3 integrates into several essential developmental signaling cascades. It is involved in the Wnt signaling pathway influential in cell fate determination embryonic development and homeostasis of adult tissues. In addition IRX3 links with the Hedgehog signaling pathway integral to developmental processes. It functions alongside other proteins such as IRX5 to modulate these pathways’ activities illustrating its role in complex gene interactions and signaling networks.\u003cbr\u003e\nStudies connect IRX3 to obesity and metabolic syndrome. Variations in the gene locus near IRX3 significantly impact fat distribution and insulin sensitivity. IRX3 may also associate with cardiac disorders as alterations in its expression levels are influenced by its role in heart development. IRX3 interacts with proteins like FTO showing a direct link to metabolic phenotypes and their pathological manifestations.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860466421929,"sku":"ab274328","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab274328","provider":"Iright","version":"1.0","type":"link"}