{"product_id":"abcam-ab275018","title":"Abcam, ab275018, Exosome Panel (Calnexin, CD9, CD63, CD81, Hsp70, TSG101)","description":"\u003cp\u003eSize: 1Kit\u003cbr\u003e\nExosome Panel containing 6 antibodies against Calnexin, CD9, CD63, CD81, Hsp70, TSG101 - Provided as a sampler panel to allow you to easily evaluate each in your required applications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nTarget:CANXSee target data\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nExosome Panel (Calnexin, CD9, CD63, CD81, Hsp70, TSG101) (ab275018) is a panel of 6 rabbit recombinant monoclonal antibodies specific to exosome markers. Exosomes are small extracellular vesicles involved in cell communication, biomolecule transport and disease processes.\u003cbr\u003e\nThis panel contains antibodies to Calnexin (UniProt: P27824), CD9 (UniProt: P21926), CD63 (UniProt: P08962), CD81 (UniProt: P60033), Hsp70 (UniProt: P17879) and TSG101 (UniProt: Q99816) in convenient trial sizes (20 µL) to allow for efficient and cost-effect testing of the antibodies simultaneously.\u003cbr\u003e\nThe individual antibodies included in this panel are:\u003cbr\u003e\nRabbit recombinant monoclonal anti-Calnexin antibody [EPR3633(2)] - ER Membrane Marker (\u003cbr\u003e\nab133615\u003cbr\u003e\nRabbit recombinant monoclonal anti-CD9 antibody [EPR23105-125] (\u003cbr\u003e\nab263019\u003cbr\u003e\nRabbit recombinant monoclonal anti-CD63 antibody [EPR5702] - Late Endosome Marker (\u003cbr\u003e\nab134045\u003cbr\u003e\nRabbit recombinant monoclonal anti-CD81 antibody [EPR21916] (20µL) (\u003cbr\u003e\nab219209\u003cbr\u003e\nRabbit recombinant monoclonal anti-Hsp70 antibody [EPR16892] (\u003cbr\u003e\nab181606\u003cbr\u003e\nRabbit recombinant monoclonal anti-TSG101 antibody [EPR7130(B)] (\u003cbr\u003e\nab125011\u003cbr\u003e\nAll of these component antibodies are available for purchase individually using their corresponding abIDs.\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcams high quality validation processes ensure each component antibody is sensitive and specific to the target protein.\u003cbr\u003e\nAll antibodies in this panel have been validated in human samples in a variety of applications, and some also have reactivity in other species.\u003cbr\u003e\nFor information on the species reactivity and application validation of each antibody within the panel, please consult the individual datasheet for each antibody. Suggested dilution factor and additional information on protocols can also be found on the antibody datasheets.\u003cbr\u003e\nAll antibodies in this panel have a minimum of 50 citations in peer-reviewed journals and are trusted by scientific community.\u003cbr\u003e\nRelated Products\u003cbr\u003e\nMany of our antibody clones are also available as carrier-free formulations for easy conjugation to labels of your choice, or in pre-conjugated formats. Please search the clone name for alternative formulations and related products.\u003cbr\u003e\nExplore our range of antibody sample panels designed to provide you with a variety of trial-size antibodies in a convenient and cost-effective format.\u003cbr\u003e\nCarrier-free formulations of our recombinant antibodies are also available for easy conjugation to labels of your choice and for multiplex applications. Use our intuitive search and select carrier-free or your label of choice. For bespoke conjugations or large volumes email bespoke@abcam.com.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTSG101 Calnexin CD9 CD63 CD81 and Hsp70 each have distinct mechanical roles in the cell. TSG101 also known as Tumor Susceptibility Gene 101 is a 46 kDa protein that plays an important role in endosomal sorting and is present in many tissues. Calnexin is a 90 kDa protein found in the endoplasmic reticulum involved in protein folding and quality control. The tetraspanins CD9 CD63 and CD81 are present on various cell surfaces with CD63 often found in late endosomes and lysosomes. CD9 and CD81 are smaller approximately 24-26 kDa. Hsp70 a heat shock protein of about 70 kDa functions as a molecular chaperone and is expressed under stress conditions in most cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins are involved in several essential cellular functions. TSG101 is part of the ESCRT-I complex which is important for membrane budding processes such as multivesicular body (MVB) formation and virus budding. Calnexin plays a role in the calnexin cycle ensuring proper protein folding in conjunction with Hsp70 which helps in protein stability and refolding damaged proteins during stress. CD9 CD63 and CD81 serve as exosome markers influencing exosome biogenesis and cargo sorting. They also play important roles in cell fusion migration and adhesion through interactions with integrins and other surface proteins.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese proteins participate in key biological processes. TSG101 operates in the endocytic pathway marking proteins for degradation or recycling within the lysosome; it works alongside ubiquitin-related processes. Calnexin assists in the ER-associated degradation pathway maintaining protein homeostasis. CD9 CD63 and CD81 are integral in the extracellular vesicle pathway facilitating the transport of proteins and RNA. They also interact with integrins and other tetraspanins impacting cellular communication and immune response. Hsp70 supports these pathways by managing protein stability and cellular stress responses.\u003cbr\u003e\nAbnormal expression of these proteins can lead to significant health issues. TSG101 mutations have links to cancer particularly breast cancer where overexpressed CD63 an exosome marker plays a role in tumor metastasis. Defects in Calnexin can result in glycoprotein misfolding and are associated with neurodegenerative diseases like Alzheimer's. Additionally CD9 is often implicated in fertility problems due to its involvement in gamete fusion. Hsp70 through its stress response role is relevant in neurodegenerative disorders where it helps mitigate protein aggregation. These connections highlight their importance in disease pathways and potential as therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847584174249,"sku":"ab275018","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab275018","provider":"Iright","version":"1.0","type":"link"}