{"product_id":"abcam-ab277619","title":"Abcam, ab277619, Anti-AC3 antibody [1A12]","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nMouse Monoclonal AC3 antibody. Suitable for IHC and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Rat Adcy3 conjugated to Keyhole Limpet Haemocyanin.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:1A12,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat,\u003cbr\u003e\nApplications:IHCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Rat Adcy3 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.P21932\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification notes-Purified from Tissue Culture supernatant., Storage buffer-Preservative: 0.03% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein AC3 also known as 'Adcy3' functions as an adenylate cyclase enzyme. This enzyme plays a significant mechanical role by converting ATP (adenosine triphosphate) to cyclic AMP (cAMP) which acts as a secondary messenger in various signaling pathways. It is also referred to as '1a12' in some studies. Weighing approximately 137 kDa AC3 is mainly expressed in the olfactory epithelium where it contributes to odor detection the brain and other tissues at lower levels. This protein operates at the cell membrane where it interacts with G proteins to mediate signal transduction processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAdenylate cyclase 3 (AC3) serves as an essential component in sensory signal transduction and is part of the adenylyl cyclase complex. It plays an important role in the conversion of external stimuli into intracellular signals important for processes like olfaction and hormonal response. Within neurons AC3 influences synaptic plasticity and learning by regulating cAMP levels. This modulation affects various neural activities and responses making AC3 important for central nervous system functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nAC3 is integrally involved in the G-protein coupled receptor (GPCR) signaling pathways. These pathways involve the activation of AC3 by G-proteins leading to enhanced production of cAMP which subsequently activates protein kinase A (PKA). AC3 collaborates with other adenylate cyclases and G-protein subunits such as Gα and Gβγ within these pathways. This intricate signaling cascade influences cellular responses to hormones and neurotransmitters and alters gene expression through cAMP-mediated pathways.\u003cbr\u003e\nAC3 has associations with conditions like obesity and depression. Abnormalities in AC3 function or expression can lead to impaired cAMP signaling disrupting normal metabolic and neurological processes. Research indicates that AC3 interacts with the melanocortin-4 receptor (MC4R) in regulating energy homeostasis and body weight linking it to obesity. In depression altered AC3 levels impact neurotransmitter signaling contributing to mood disorders. Understanding AC3's role in these conditions may offer therapeutic insights into disease management.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854756040873,"sku":"ab277619","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab277619","provider":"Iright","version":"1.0","type":"link"}