{"product_id":"abcam-ab282287","title":"Abcam, ab282287, Anti-ProCathepsin B antibody [EPR24353-25] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Cathepsin B antibody. Carrier free. Suitable for Flow Cyt (Intra), WB, IHC-P and reacts with Mouse, Human, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24353-25,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab282287 is the carrier-free version of\u003cbr\u003e\nab270998\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProCathepsin B also known as Cathepsin B precursor or CTSB is a cysteine protease with a mature form mass of around 37 kDa. This protein begins as an inactive zymogen requiring processing to become active. It expresses mainly in lysosomes but can also be found extracellularly particularly in disease states. Typically abundant in various tissues ProCathepsin B undergoes proteolytic activation by removal of its propeptide region to function effectively in proteolysis.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nProCathepsin B facilitates protein catabolism by degrading extracellular matrix components. It does not commonly form part of a larger protein complex allowing it to perform its proteolytic activity independently. The protein's actions are important for cellular turnover and tissue remodeling. In healthy tissues ProCathepsin B supports normal cellular homeostasis but dysregulation can lead to pathological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nProCathepsin B plays a role in the proteolytic pathways involving processes such as autophagy and apoptosis. It participates in the ubiquitin-proteasome pathway interrelated with proteins like Ubiquitin and Caspases. These pathways control protein degradation and programmed cell death highlighting ProCathepsin B's importance in maintaining cellular function and regulation.\u003cbr\u003e\nProCathepsin B is associated with conditions like cancer and arthritis. In cancer its overexpression facilitates tumor invasion and metastasis often linked with proteins such as Matrix Metalloproteinases (MMPs). In arthritis increased ProCathepsin B activity contributes to joint tissue breakdown connecting with Collagen too. These associations make ProCathepsin B a potential target for therapeutic intervention in such disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848562331817,"sku":"ab282287","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab282287","provider":"Iright","version":"1.0","type":"link"}