{"product_id":"abcam-ab282423","title":"Abcam, ab282423, WH-4-023","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 568.7 Da, Purity \u0026gt;98%. Potent and selective inihbitor of the tyrosine kinases Lck and Src with IC 50  values of 2 nM for Lck and 6 nM for Src.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:837422-57-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:PowderSee storage information,\u003cbr\u003e\nMolecular weight:568.7 Da,\u003cbr\u003e\nMolecular formula:C32H36N6O4,\u003cbr\u003e\nPubChem:11844351,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO: 20 mg\/ml.,\u003cbr\u003e\nBiochemical name:2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate,\u003cbr\u003e\nBiological description:Potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src.,\u003cbr\u003e\nCanonical smiles:CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C,\u003cbr\u003e\nInChi:InChI=1S\/C32H36N6O4\/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37\/h6-16,21H,17-20H2,1-5H3,(H,33,34,35),\u003cbr\u003e\nInChiKey:NBTNHSGBRGTFJS-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:(2,6-dimethylphenyl) N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamate\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe targets p38 Src VEGF Receptor 2 and Lck play significant roles in various cellular processes. p38 also known as MAPK14 is part of the mitogen-activated protein kinase (MAPK) family and it has a mass of about 41 kDa. It is widely expressed in many tissues like the heart skeletal muscle and liver. Src a non-receptor tyrosine kinase weighs approximately 60 kDa and resides in the cytoplasm and membranes of cells. VEGF Receptor 2 also known as KDR or FLK-1 is integral to cell signaling and shows a molecular weight of 150 kDa. It is found in endothelial cells facilitating vascular growth. Lck a lymphocyte-specific tyrosine kinase with a mass of roughly 56 kDa localizes mainly in T-cells and is important for T-cell receptor signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins perform essential functions in cellular signaling. p38 for instance regulates inflammatory responses by activating downstream effectors in stress-stimulated pathways. Src plays a significant role in the regulation of cell division and survival by interacting with various signal transducers. VEGF Receptor 2 is fundamental to angiogenesis a process vital for new blood vessel formation. It participates in a complex with VEGF to transmit signals for endothelial cell proliferation. Lck functions in the immune system by initiating the signaling cascade necessary for T-cell activation and development.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese proteins impact significant cellular communication networks. p38 is an important player in the MAPK pathway involved in responses to stress stimuli. It interacts with other MAPKs like JNK in controlling cytokine production. Src integrates into the Src-family kinase pathway modulating cell growth and movement by activating downstream proteins such as FAK. VEGF Receptor 2 is pivotal in the VEGF signaling pathway partnering with PI3K and AKT to promote endothelial cell responses. Lck fits into the T-cell receptor pathway where it associates with proteins like ZAP-70 to relay activation signals.\u003cbr\u003e\nThese targets link to several pathological conditions. p38 plays an essential role in inflammatory diseases like arthritis where it mediates inflammatory cytokine production. Src is implicated in cancer carrying mutations or overexpressions in various malignancies often accompanied by proteins such as FAK that drive tumor progression. VEGF Receptor 2 contributes to angiogenesis-related disorders including cancer where its pathway's overactivation supports tumor vasculature development. Lck links with immune disorders like autoimmune diseases as improper signaling here leads to abnormal T-cell responses. In these contexts therapeutic targeting of these proteins can provide compelling strategies to mitigate disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847429673129,"sku":"ab282423","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab282423","provider":"Iright","version":"1.0","type":"link"}