{"product_id":"abcam-ab282443","title":"Abcam, ab282443, Compound 56","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 388.3 Da, Purity \u0026gt;97%. Cell-permeable, reversible and ATP-competitive, potent and specific inhibitor of tyrosine kinase activity of EGFR.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:171745-13-4,\u003cbr\u003e\nPurity:\u0026gt;97%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:388.3 Da,\u003cbr\u003e\nMolecular formula:C18H18BrN3O2,\u003cbr\u003e\nPubChem:2857,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:≥16.95mg\/mL in DMSO. Insoluble in H2O.,\u003cbr\u003e\nBiochemical name:N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine,\u003cbr\u003e\nBiological description:Cell-permeable, reversible and ATP-competitive, potent and specific inhibitor of tyrosine kinase activity of EGFR.,\u003cbr\u003e\nCanonical smiles:CCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OCC,\u003cbr\u003e\nInChi:InChI=1S\/C18H18BrN3O2\/c1-3-23-16-9-14-15(10-17(16)24-4-2)20-11-21-18(14)22-13-7-5-6-12(19)8-13\/h5-11H,3-4H2,1-2H3,(H,20,21,22),\u003cbr\u003e\nInChiKey:YXOXHAUUTIOBDA-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-(3-bromophenyl)-6,7-diethoxyquinazolin-4-amine\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEGFR also known as Epidermal Growth Factor Receptor and FBP1 or Fructose-16-bisphosphatase 1 plays important roles in different cellular processes. EGFR is a transmembrane glycoprotein and falls within the receptor tyrosine kinases family with a molecular weight of approximately 170 kDa. It is widely expressed in epithelial tissues and involved in cell signaling pathways. FBP1 on the other hand functions as a gluconeogenic enzyme mainly found in the liver and kidney with a molecular weight of about 37 kDa. These proteins each perform distinct roles to maintain proper cellular function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEGFR is involved in regulating cell growth differentiation and survival. As part of a signal transduction complex it accommodates ligand binding that triggers dimerization and activation leading to multiple intracellular pathways. FBP1 acts as an important regulator in gluconeogenesis maintaining the balance of glucose production during fasting states. FBP1 does not typically associate with protein complexes in its functionality focusing on the conversion of fructose-16-bisphosphate to fructose-6-phosphate in the cytoplasm.\u003cbr\u003e\nPathways\u003cbr\u003e\nEGFR significantly contributes to the MAPK\/ERK and PI3K\/AKT signaling pathways which are essential for mediating cellular responses to external growth factors. These pathways connect EGFR with proteins like RAF MEK and AKT which carry out further signaling cascades. FBP1 primarily participates in metabolic pathways and has a more isolated role interacting less with other proteins in these complex signaling networks.\u003cbr\u003e\nBoth EGFR and FBP1 link to specific pathologies. EGFR is often associated with various cancers like non-small cell lung cancer highlighting its role in tumor cell proliferation through interactions with proteins like HER2. Mutations in its gene amplify signaling susceptibility contributing to oncogenesis. On the other hand FBP1 is linked to metabolic disorders such as hypoglycemia due to impaired gluconeogenesis. In these cases reduced enzymatic activity leads to glucose imbalance but it has fewer direct interactions with other proteins in the context of disease states.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847430131881,"sku":"ab282443","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab282443","provider":"Iright","version":"1.0","type":"link"}