{"product_id":"abcam-ab28280","title":"Abcam, ab28280, Anti-Calpain 5 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal Calpain 5 antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CAPN5 aa 1-50.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human CAPN5 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O15484,\u003cbr\u003e\nSpecificity:Does not cross react with the other calpain family members (Calpain 1, Calpain 2, Calpain 3, ncl 3, etc.).\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nDiluted antibody can be reused several times if not contaminated; store at 4°C with 0.05% Sodium Azide as preservative.\u003cbr\u003e\nab28280 does not recognize amino-processed Calpain 5, and can be used to discriminate between latent and amino-processed forms. ab28280 will also bind to the non-reduced protein, and thus may have application for immunoprecipitation, immunohistochemistry, and ELISA.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-The antibody has been peptide-affinity purified., Storage buffer-Preservative: 0.05% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCalpain 5 also known as PalBH is a non-classical member of the calpain family with a mass of approximately 80 kilodaltons. Calpain 5 is made from a calcium-dependent cysteine protease showing expression in tissues like the retina and neurons. Known for its calpain-like protease domain and an extended C-terminal region Calpain 5 lacks the typical EF-hand motifs found in other calpains.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCalpain 5 acts without forming complexes with calmodulin or calpastatin which is common in other calpain family members. It modulates cellular processes such as cytoskeleton remodeling and cellular signaling. It plays roles in cell cycle progression and apoptosis by regulating molecules involved in these processes. Calpain 5 interacts with cytoskeletal proteins and promotes degradation or remodeling facilitating normal cellular function and adaptation to stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nCalpain 5 functions are relevant in signal transduction and apoptosis pathways. In signal transduction it participates in protein kinase C-related pathways where it modulates protein activity critical for cell communication. Regarding apoptosis Calpain 5 interacts with BCL-2 family proteins which are key regulators of cell death influencing cell survival outcomes.\u003cbr\u003e\nMutations or dysregulation of Calpain 5 associate with retinal disorders like vitelliform macular dystrophy and cone-rod dystrophy. These conditions involve Calpain 5 in the deterioration of retinal cells likely through interactions with retinal proteins such as CRX and RDH12. Understanding Calpain 5's role in these disorders may offer insights into new therapeutic approaches for degeneration of retinal cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854147375273,"sku":"ab28280","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab28280","provider":"Iright","version":"1.0","type":"link"}