{"product_id":"abcam-ab284629","title":"Abcam, ab284629, Anti-SARS-CoV-2 nsp15 antibody [EPR24840-74]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal R1AB antibody. Suitable for WB, IHC-P, I-ELISA, ICC\/IF, Flow Cyt and reacts with SARS-CoV-2, Recombinant full length protein - SARS-CoV-2 samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24840-74,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:SARS-CoV-2,\u003cbr\u003e\nApplications:ICC\/IF, WB, Flow Cyt, I-ELISA, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.01% Sodium azideConstituents: 59.94% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSARS-CoV-2 nsp15 also known as non-structural protein 15 is an endoribonuclease with uridine-specific activity. It is expressed in the cytoplasm of cells infected by the virus. Nsp15 has a monomer mass of approximately 42 kDa. In its active form it typically assembles into a hexameric complex which is important for its enzymatic function. It helps in evading the host immune response by degrading double-stranded RNA intermediates preventing detection by the host's antiviral pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNsp15 is an important participant in the viral replication machinery of SARS-CoV-2. Nsp15 as part of the replication and transcription complex processes viral RNA to promote efficient replication. This protein may interact indirectly with other non-structural proteins such as nsp8 and nsp12 which form part of the RNA-dependent RNA polymerase complex. By maintaining the integrity of viral RNA nsp15 ensures successful virus propagation.\u003cbr\u003e\nPathways\u003cbr\u003e\nNsp15 plays a significant role in the viral life cycle particularly in the genome replication and transcription pathways. This protein is connected to nsp10 and nsp14 which are involved in RNA proofreading and capping. These interactions support the virus in overcoming innate immune responses by ensuring proper RNA processing and replication. Through these pathways nsp15 contributes significantly to the viral survival and proliferation within the host.\u003cbr\u003e\nNsp15 is primarily linked to COVID-19. Its role in immune evasion makes it a target of interest in the study of viral pathogenesis and therapeutic interventions. Research has indicated potential interactions between nsp15 and host proteins that could impact disease progression. Furthermore its manipulation or inhibition could serve as a therapeutic strategy potentially reducing the ability of SARS-CoV-2 to spread within the host. Understanding these interactions could aid in the development of antiviral drugs targeting nsp15 specifically.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855740326057,"sku":"ab284629","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab284629","provider":"Iright","version":"1.0","type":"link"}