{"product_id":"abcam-ab284845","title":"Abcam, ab284845, Anti-C10orf35 antibody [EP14950-82] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal C10orf35 antibody. Carrier free. Suitable for IP, WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP14950-82,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Rat, Human, Mouse,\u003cbr\u003e\nApplications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab284845 is the carrier-free version of\u003cbr\u003e\nab189923\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC10orf35 also known as Chromosome 10 Open Reading Frame 35 encodes a protein with a mass of approximately 86 kDa. This protein primarily localizes to the cytoplasm and shows significant expression in various tissues including the testis brain and heart. Its exact mechanical role remains not fully understood but it is suggested to be involved in cellular processes related to structural organization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nC10orf35 interacts with cellular components often associated with maintaining cellular architecture and signaling pathways. It does not typically form part of well-defined protein complexes yet it still contributes to the integrity and function of specialized cells. The expression pattern hints at a mechanism influencing cell differentiation and proliferation particularly in reproductive and neural tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers have linked C10orf35 to significant cellular signaling and development pathways including the Wnt\/β-catenin signaling pathway and the Hedgehog signaling pathway. These pathways play critical roles in cell fate determination and embryonic development. C10orf35 shows interaction with proteins like β-catenin and Hedgehog influencing downstream signaling events critical for transcriptional regulation and morphogenetic processes.\u003cbr\u003e\nResearchers investigated the involvement of this target in developmental disorders and cancers particularly testicular cancer. The malfunction or abnormal expression of C10orf35 can disrupt cellular homeostasis leading to uncontrolled cell proliferation and differentiation. Its interaction with β-catenin is particularly notable in cancer-related research suggesting potential as a therapeutic target for modulating oncogenic pathways.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860557779113,"sku":"ab284845","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab284845","provider":"Iright","version":"1.0","type":"link"}