{"product_id":"abcam-ab285288","title":"Abcam, ab285288, Human TERT ELISA Kit","description":"\u003cp\u003eSize: 96Test\u003cbr\u003e\nHuman TERT ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human TERT in in Biofluids, Cell\/Tissue Extracts, Cell Culture Media samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Plasma, Tissue Homogenate, Cell culture supernatant, Serum, Other biological fluids,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:\u0026lt; 0.094 ng\/mL,\u003cbr\u003e\nRange:0.156 - 10 ng\/mL,\u003cbr\u003e\nAssay Platform:Microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis Telomerase reverse transcriptase (TERT) ELISA kit (ab285288, K4187) is a sandwich ELISA assay for the quantitative measurement of human TERT in serum, plasma and cell culture supernatants. The density of color is proportional to the amount of TERT captured from the samples.\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called K4187 TERT (Human) ELISA Kit. K4187-100 is the same size as the 96 test size of ab285288.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTelomerase reverse transcriptase also known as TERT is an enzyme with a molecular mass of about 127 kDa. It functions as a catalytic subunit of the telomerase complex which extends telomeres by adding the nucleotide sequence \"TTAGGG\" to the ends of chromosomes. TERT operates with a telomerase RNA component (TERC) to synthesize DNA using an RNA template a process called reverse transcription. TERT is expressed in embryonic tissues adult stem cells and cancer cells where rapid cell division occurs.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTERT plays an important role in maintaining telomere length essential for protecting chromosome stability. The protein forms part of the telomerase holoenzyme complex working together with TERC to perform its function. Telomerase activity allows cells to bypass the Hayflick limit preventing senescence and enhancing replication potential. In addition to telomere maintenance TERT influences gene regulation and cellular proliferation.\u003cbr\u003e\nPathways\u003cbr\u003e\nTERT holds significance in the telomere maintenance and signaling pathways. Telomere maintenance ensures genomic integrity and cellular longevity a process fundamental for tissue homeostasis and regeneration. TERT interacts with proteins such as dyskerin and TERC within these pathways. Its regulatory roles in these pathways also reveal interactions with other key proteins like hypothesized targets in the DNA damage response.\u003cbr\u003e\nThe upregulation of TERT is associated with cancer and degenerative diseases. Increased telomerase activity is a common feature in many cancers leading to uncontrolled cell proliferation. Additionally mutations in TERT and its associated components can contribute to disorders like dyskeratosis congenita a rare genetic condition resulting in bone marrow failure. In these conditions TERT interaction with proteins involved in chromosomal maintenance and repair becomes important for understanding disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843796258985,"sku":"ab285288","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab285288","provider":"Iright","version":"1.0","type":"link"}