{"product_id":"abcam-ab285398","title":"Abcam, ab285398, GLPG-1690","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 588.7 Da, Purity \u0026gt;98%. Selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1628260-79-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:588.7 Da,\u003cbr\u003e\nMolecular formula:C30H33FN8O2S,\u003cbr\u003e\nPubChem:90420193,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO,\u003cbr\u003e\nBiochemical name:Ziritaxestat,\u003cbr\u003e\nBiological description:Selective autotaxin inhibitor with potential application in idiopathic pulmonary disease (IPF).,\u003cbr\u003e\nCanonical smiles:CCC1=C(N2C=C(C=C(C2=N1)C)N3CCN(CC3)CC(=O)N4CC(C4)O)N(C)C5=NC(=C(S5)C#N)C6=CC=C(C=C6)F,\u003cbr\u003e\nInChi:InChI=1S\/C30H33FN8O2S\/c1-4-24-29(35(3)30-34-27(25(14-32)42-30)20-5-7-21(31)8-6-20)39-15-22(13-19(2)28(39)33-24)37-11-9-36(10-12-37)18-26(41)38-16-23(40)17-38\/h5-8,13,15,23,40H,4,9-12,16-18H2,1-3H3,\u003cbr\u003e\nInChiKey:REQQVBGILUTQNN-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-[[2-ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]-methylamino]-4-(4-fluorophenyl)-1,3-thiazole-5-carbonitrile\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B1850 GLPG-1690. B1850-25 is the same size as the 25 mg size of ab285398.\u003cbr\u003e\nProtect from air and light.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nENPP2 also known as Autotaxin (ATX) is a multifunctional enzyme with phosphodiesterase activity. It breaks down lysophosphatidylcholine into lysophosphatidic acid (LPA) and glycerol phosphate. With a molecular mass of approximately 100 kDa ENPP2 is secreted into extracellular environments. This protein is mainly expressed in adipose tissue but researchers found its presence in other tissues such as the brain and the liver as well.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nENPP2\/ATX plays an important role in processes like cell proliferation migration and survival by producing LPA a bioactive lysophospholipid. LPA acts as a signaling molecule by binding to its specific G-protein-coupled receptors. ENPP2 exists as a monomer and does not form a stable part of a larger protein structure. Its enzymatic activity in generating LPA influences various cellular responses and physiologic states.\u003cbr\u003e\nPathways\u003cbr\u003e\nIt is evident that ENPP2 is involved in the LPA signaling pathway and metabolic processes related to phospholipids. The LPA signaling pathway in particular links ENPP2 to proteins such as LPAR1 and LPAR2 which bind LPA and initiate downstream effects. ENPP2's enzymatic product LPA further participates in pathways influencing cellular responses like inflammation and angiogenesis.\u003cbr\u003e\nResearch highlights ENPP2's involvement in diseases such as cancer and fibrosis. ENPP2 activity is upregulated in several cancers leading to enhanced tumor cell motility and invasion. It is also linked to fibrosis particularly liver fibrosis due to its role in producing LPA which promotes fibrotic responses. In the context of these diseases ENPP2 interacts with proteins like MMPs (matrix metalloproteinases) in cancer invasion exemplifying its contribution to pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847500452009,"sku":"ab285398","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab285398","provider":"Iright","version":"1.0","type":"link"}