{"product_id":"abcam-ab286909","title":"Abcam, ab286909, Anti-SARS-CoV-2 nsp13 antibody [EPR24838-18]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal R1AB antibody. Suitable for ICC\/IF, Flow Cyt (Intra), I-ELISA, WB and reacts with Recombinant full length protein - SARS-CoV-2, Recombinant fragment - SARS-CoV-2 samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24838-18,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:SARS-CoV-2,\u003cbr\u003e\nApplications:I-ELISA, ICC\/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSARS-CoV-2 nsp13 also known as the helicase protein is a non-structural protein involved in the replication of the virus SARS-CoV-2. Weighing around 66 kDa this protein is expressed in the infected host cells. Nsp13 exhibits RNA helicase activity unwinding RNA secondary structures and equipped with 5'-triphosphatase activity it facilitates RNA replication and transcription. It ensures full-length synthesis of viral RNAn important for viral proliferation and genome stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNsp13 contributes in processes essential for SARS-CoV-2's lifecycle. This protein acts as a part of the viral replication and transcription complex where it coordinates with other non-structural proteins. Within this complex it maintains its helicase function which is imperative for elongating the nascent RNA strand. Nsp13 binds with nsp12 the RNA-dependent RNA polymerase playing a critical role in synthesizing viral RNA through successfully clearing RNA-based hindrances.\u003cbr\u003e\nPathways\u003cbr\u003e\nSARS-CoV-2 nsp13 is involved in the viral replication and host cell interaction pathway fundamentally impacting host cellular machinery. Considered a critical player in the viral life cycle it interacts with proteins like nsp8 and nsp12 enhancing RNA synthesis and processing activities in the virus. These interactions position nsp13 as a target in antiviral drug development efforts aiming to disrupt viral RNA synthesis pathways.\u003cbr\u003e\nSARS-CoV-2 nsp13 has a direct relationship with COVID-19 the disease caused by SARS-CoV-2 infection. This protein contributes to the pathogenesis of COVID-19 by assisting in viral replication facilitating the virus's survival within the host. Research also links nsp13 function to immune system challenges as it associates with proteins like nsp14 involved in evading host immune responses worsening the clinical outcomes in COVID-19 patients.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845021651113,"sku":"ab286909","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab286909","provider":"Iright","version":"1.0","type":"link"}