{"product_id":"abcam-ab286989","title":"Abcam, ab286989, BMS-986020","description":"\u003cp\u003eSize: 25mg\u003cbr\u003e\nMW 482.5 Da, Purity \u0026gt;98%. Potent G protein-coupled lysophosphatidic acid receptor 1 (LPA1) antagonist. LPA receptor is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions, such as cell proliferation, platelet aggregation, smooth muscle contraction and others.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1257213-50-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:482.5 Da,\u003cbr\u003e\nMolecular formula:C29H26N2O5,\u003cbr\u003e\nPubChem:49792850,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO (~20 mg\/ml),\u003cbr\u003e\nBiochemical name:Cyclopropanecarboxylic acid, 1-[4'-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1'-biphenyl]-4-yl]-,\u003cbr\u003e\nBiological description:Potent G protein-coupled lysophosphatidic acid receptor 1 (LPA1) antagonist. LPA receptor is involved in binding of the signaling molecule lysophosphatidic acid, which in turn is involved in a host of diverse biological functions, such as cell proliferation, platelet aggregation, smooth muscle contraction and others.,\u003cbr\u003e\nCanonical smiles:CC1=NOC(=C1NC(=O)OC(C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O,\u003cbr\u003e\nIsomeric smiles:CC1=NOC(=C1NC(=O)O[C@H](C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5(CC5)C(=O)O,\u003cbr\u003e\nInChi:InChI=1S\/C29H26N2O5\/c1-18-25(30-28(34)35-19(2)20-6-4-3-5-7-20)26(36-31-18)23-10-8-21(9-11-23)22-12-14-24(15-13-22)29(16-17-29)27(32)33\/h3-15,19H,16-17H2,1-2H3,(H,30,34)(H,32,33)\/t19-\/m1\/s1,\u003cbr\u003e\nInChiKey:GQBRZBHEPUQRPL-LJQANCHMSA-N,\u003cbr\u003e\nIUPAC Name:1-[4-[4-[3-methyl-4-[[(1R)-1-phenylethoxy]carbonylamino]-1,2-oxazol-5-yl]phenyl]phenyl]cyclopropane-1-carboxylic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2290 BMS-986020. B2290-25 is the same size as the 25 mg size of ab286989.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Storage information-This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nEDG2 also known as LPA-1 LPAR1 or lysophosphatidic acid receptor 1 acts as a receptor for LPA (lysophosphatidic acid) a bioactive lipid mediator. This protein has a molecular mass of approximately 41 kDa. It is part of the G protein-coupled receptor (GPCR) family. EDG2 is mainly expressed in organs such as the brain heart and lungs. It plays an important role in cellular signal transduction by binding LPA which leads to various cellular responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nEDG2\/LPA-1 influences several cellular processes including cell proliferation migration and survival. It does not function as part of a larger complex; instead it activates intracellular signaling cascades upon LPA binding. This activation leads to downstream effects that regulate processes like cytoskeletal reorganization and gene expression. Its influence extends to immune response modulation making it significant in understanding cellular behavior and communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nEDG2\/LPA-1 is important in the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K\/AKT) signaling pathways. These pathways affect cell growth survival and metabolism showcasing the receptor's importance in cellular regulation. Through these pathways EDG2 interacts with multiple proteins including RAC1 a small GTPase involved in cytoskeletal organization and various kinase enzymes that facilitate signal transduction.\u003cbr\u003e\nEDG2\/LPA-1 has associations with cancer and fibrosis. In cancer the receptor influences tumor growth and metastasis due to its role in cell migration and proliferation. It connects to the matrix metalloproteinases (MMPs) in this context which degrade extracellular matrix components to facilitate cancer cell invasion. Additionally in fibrotic diseases EDG2's influence on fibroblast activity leads to tissue scarring and dysfunctional repair. Understanding these connections helps to explore therapeutic targets meant to modulate EDG2\/LPA-1 activity in pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847496683689,"sku":"ab286989","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab286989","provider":"Iright","version":"1.0","type":"link"}