{"product_id":"abcam-ab287026","title":"Abcam, ab287026, SRT-3025 hydrochloride","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 606.2 Da, Purity \u0026gt;98%. SRT-3025 is a potent and selective Sirt1 activator. It inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT-3025 inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages (BMMs) by activating AMPK and deacetylating RelA\/p65 lysine 310, critical for activation of the NF-κB signaling pathway.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:2070015-26-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:606.2 Da,\u003cbr\u003e\nMolecular formula:C31H32ClN5O2S2,\u003cbr\u003e\nPubChem:118986647,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to \u0026gt;75 mM,\u003cbr\u003e\nBiochemical name:SRT3025 HCl,\u003cbr\u003e\nBiological description:SRT-3025 is a potent and selective Sirt1 activator. It inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival. SRT-3025 inhibits RANKL-induced osteoclastogenesis in bone marrow-derived macrophages (BMMs) by activating AMPK and deacetylating RelA\/p65 lysine 310, critical for activation of the NF-κB signaling pathway.,\u003cbr\u003e\nCanonical smiles:COCCCC1=C(N=C(S1)C2=CC=CC=C2)C(=O)NC3=CC=CC=C3C4=NC5=C(S4)N=CC(=C5)CN6CCCC6.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C31H31N5O2S2.ClH\/c1-38-17-9-14-26-27(35-29(39-26)22-10-3-2-4-11-22)28(37)33-24-13-6-5-12-23(24)30-34-25-18-21(19-32-31(25)40-30)20-36-15-7-8-16-36;\/h2-6,10-13,18-19H,7-9,14-17,20H2,1H3,(H,33,37);1H,\u003cbr\u003e\nInChiKey:LGRBDTOIPNDWMN-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:5-(3-methoxypropyl)-2-phenyl-N-[2-[6-(pyrrolidin-1-ylmethyl)-[1,3]thiazolo[5,4-b]pyridin-2-yl]phenyl]-1,3-thiazole-4-carboxamide;hydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2376 SRT-3025 hydrochloride. B2376-25 is the same size as the 25 mg size of ab287026.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847497896105,"sku":"ab287026","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab287026","provider":"Iright","version":"1.0","type":"link"}