{"product_id":"abcam-ab287090","title":"Abcam, ab287090, GW-311616A","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 434 Da, Purity \u0026gt;98%. A potent and selective intracellular neutrophil elastase (NE, alpha-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC 50  values of 22 nM for HNE, \u0026gt;100 μM for trypsin, cathepsin G and plasmin, \u0026gt;3 μM for chymotrypsin and tissue plasminogen activator.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:197890-44-1,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:434 Da,\u003cbr\u003e\nMolecular formula:C19H32ClN3O4S,\u003cbr\u003e\nPubChem:9889108,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSOSoluble in Water,\u003cbr\u003e\nBiochemical name:GW311616 hydrochloride,\u003cbr\u003e\nBiological description:A potent and selective intracellular neutrophil elastase (NE, alpha-1-proteinase) inhibitor. Inhibits human neutrophil elastase (HNE) and is selective over other human serine proteases with IC50 values of 22 nM for HNE, \u0026gt;100 μM for trypsin, cathepsin G and plasmin, \u0026gt;3 μM for chymotrypsin and tissue plasminogen activator.,\u003cbr\u003e\nCanonical smiles:CC(C)C1C2C(CCN2C(=O)C=CCN3CCCCC3)N(C1=O)S(=O)(=O)C.Cl,\u003cbr\u003e\nIsomeric smiles:CC(C)[C@H]1[C@H]2[C@@H](CCN2C(=O)\/C=C\/CN3CCCCC3)N(C1=O)S(=O)(=O)C.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C19H31N3O4S.ClH\/c1-14(2)17-18-15(22(19(17)24)27(3,25)26)9-13-21(18)16(23)8-7-12-20-10-5-4-6-11-20;\/h7-8,14-15,17-18H,4-6,9-13H2,1-3H3;1H\/b8-7+;\/t15-,17+,18-;\/m1.\/s1,\u003cbr\u003e\nInChiKey:UFCZUKYPBPXODT-OFTZGUNKSA-N,\u003cbr\u003e\nIUPAC Name:(3aR,6S,6aS)-4-methylsulfonyl-1-[(E)-4-piperidin-1-ylbut-2-enoyl]-6-propan-2-yl-3,3a,6,6a-tetrahydro-2H-pyrrolo[3,2-b]pyrrol-5-one;hydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2559 GW-311616A. B2559-5 is the same size as the 5 mg size of ab287090.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeutrophil Elastase also known as neutrophil proteinase 3 has a molecular mass of approximately 30 kDa. It is a serine protease expressed mainly in azurophilic granules of neutrophils. This enzyme breaks down various proteins including elastin at sites of inflammation. Neutrophil Elastase releases during degranulation or through neutrophil extracellular traps (NETs) to combat pathogens.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe target plays a significant role in neutrophil-mediated tissue remodeling and host defense. It leads to the breaking down of extracellular matrix components contributing to tissue remodeling and repair. Neutrophil Elastase is part of a complex interplay with other proteases like matrix metalloproteinases (MMPs). Its activity is regulated by endogenous inhibitors such as alpha-1 antitrypsin to prevent excessive tissue damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protease is important in inflammation and immune response pathways. It plays a role in the complement system by activating C5 a component of the complement cascade. It also acts in conjunction with other proteases such as cathepsin G to modulate immune and inflammatory responses. Neutrophil Elastase's role within these pathways is pivotal for the regulation of inflammation and destruction of pathogens.\u003cbr\u003e\nIndividuals with conditions such as chronic obstructive pulmonary disease (COPD) and cystic fibrosis often exhibit dysregulation or excessive activity of Neutrophil Elastase. This excessive activity leads to tissue damage and exacerbates disease progression. The enzyme also interacts with proteins like elastin and collagen in these diseases further contributing to pathological tissue remodeling and damage.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847429312681,"sku":"ab287090","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab287090","provider":"Iright","version":"1.0","type":"link"}