{"product_id":"abcam-ab300036","title":"Abcam, ab300036, Anti-PTCH2 antibody [EPR26073-39]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal PTCH2 antibody. Suitable for WB, IHC-P, ICC\/IF, Flow Cyt (Intra), IP and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26073-39,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, IP, IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPTCH2 also known as Patched 2 is a protein with a mass of approximately 145 kDa. It is a member of the Patched family of proteins and functions as a transmembrane receptor. PTCH2 is predominantly found on the surface of cells in tissues such as skin brain and testes. The protein serves an important role in regulating the signaling of the Hedgehog pathway by binding to its ligand Sonic Hedgehog which controls the activity of the smoothened (SMO) receptor.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPTCH2 participates in the negative regulation of the Hedgehog signaling pathway. It forms a receptor complex with other proteins to maintain proper cell communication and growth control. PTCH2 is part of a larger complex that includes Patched 1 (PTCH1) contributing to embryonic development and tissue patterning. Its regulation of cellular growth and differentiation processes is critical for these activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nPTCH2 is a critical component of the Hedgehog signaling pathway and the development pathway. It closely interacts with PTCH1 and SMO in regulating signal transduction. Communication within these pathways is essential for tissue patterning and organogenesis. PTCH2's modulation of SMO results in downstream effects which impact the transcription of target genes controlling cell proliferation.\u003cbr\u003e\nPTCH2 has a link to basal cell carcinoma and medulloblastoma. Its aberrant signaling and mutations may lead to uncontrolled cellular proliferation contributing to the onset of these cancers. The protein's interaction with PTCH1 also affects cancer susceptibility since both proteins can influence the progression and risk of developing tumors associated with the Hedgehog pathway.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850402451625,"sku":"ab300036","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab300036","provider":"Iright","version":"1.0","type":"link"}