{"product_id":"abcam-ab300572","title":"Abcam, ab300572, Anti-HEPACAM antibody [EPR25296-150] (BSA and Azide free)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HEPACAM antibody. Carrier free. Suitable for IHC-P, WB and reacts with Rat, Mouse, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25296-150,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHEPACAM also known as \"glialCAM\" is a transmembrane glycoprotein that weighs approximately 55-65 kDa. It primarily appears in the glial cells of the central nervous system and plays a significant role in cell adhesion and communication. Researchers identified this protein in astrocytes oligodendrocytes and ependymal cells. It interacts with other cell adhesion molecules to mediate interactions between glial cells and contributes to maintaining the structural integrity of tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHEPACAM functions in the context of cell-cell adhesion and signal transduction mechanisms. This protein does not operate in isolation but rather forms part of larger protein complexes enhancing its role in cellular scaffolding and molecular signaling networks. The interaction with other cellular machinery supports processes like cell migration proliferation and differentiation which are critical for maintaining the homeostasis of neural tissues. Studies also highlight its role in modulating immune response and inflammatory processes within the nervous system.\u003cbr\u003e\nPathways\u003cbr\u003e\nHEPACAM integrates into specific pathways involving cellular adhesion and signal transduction such as the PI3K\/AKT signaling pathway. This pathway plays an important role in controlling cell growth and survival. HEPACAM's interaction with molecules like integrins and other cell adhesion proteins strengthens its function within this pathway. For instance integrins contribute to the regulation of the extracellular matrix composition affecting cellular movements and interactions vital for immune surveillance and responses in the nervous system.\u003cbr\u003e\nResearch associates HEPACAM with conditions like epilepsy and leukodystrophy. Alterations in HEPACAM expression or function can lead to improper cell adhesion disrupting normal tissue architecture and contributing to pathological states. Additionally there are links between HEPACAM and connexins proteins involved in forming gap junctions which further emphasizes its role in conditions characterized by impaired cellular communication. These associations highlight HEPACAM's involvement in maintaining neural stability and function within the central nervous system.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851745448105,"sku":"ab300572","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab300572","provider":"Iright","version":"1.0","type":"link"}