{"product_id":"abcam-ab306657","title":"Abcam, ab306657, Human ELAVL3 knockout U-87 MG cell line","description":"\u003cp\u003eSize: 1000000Cells \/ vial \/ 2 x 1000000Cells \/ vial\u003cbr\u003e\nELAVL3 KO cell line available to order. KO validated by Next Generation Sequencing. Free of charge wild type control available. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:U-87 MG,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Brain,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Next Generation Sequencing,\u003cbr\u003e\nDisease:Glioblastoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ELAVL3, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Next Generation Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHuC also known as ELAVL3 is a neuronal-specific RNA-binding protein part of the ELAV (embryonic lethal abnormal vision) family. It plays a mechanical role in the stabilization and transport of mRNA. HuC has a mass of approximately 36 kDa. It is expressed predominantly in neuronal tissues particularly within the brain where it engages in critical functions related to neural RNA metabolism.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHuC significantly influences neuronal differentiation and development. It participates in controlling the stability and translation of mRNA transcripts in neurons. HuC often functions as part of larger RNA-protein complexes impacting the post-transcriptional modification of target RNAs. Through its ability to bind mRNA HuC promotes the expression of proteins essential for neuron function affecting how neurons develop and maintain their activity.\u003cbr\u003e\nPathways\u003cbr\u003e\nHuC integrates into the post-transcriptional regulatory networks in neurons. It influences the MAPK signaling pathway which is important for cell proliferation and survival. Within these pathways HuC interacts with proteins such as HuD another member of the ELAV family to ensure proper mRNA processing and translational control. These interactions are vital for maintaining neuronal integrity and response to external stimuli.\u003cbr\u003e\nHuC has connections to neurodegenerative conditions such as Alzheimer's disease and certain types of cancer involving neuronal tissue. The dysfunction or aberrant expression of HuC disrupts normal neuronal function contributing to disease progression. In these contexts HuC often interacts with the Tau protein in Alzheimer's suggesting its involvement in the pathological pathways leading to cognitive decline. Additionally dysregulated interaction with other RNA-binding proteins like HuR might exacerbate disease states by altering the stability of RNA transcripts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845157179561,"sku":"ab306657","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab306657","provider":"Iright","version":"1.0","type":"link"}