{"product_id":"abcam-ab307198","title":"Abcam, ab307198, Anti-mSin3a antibody [EPR27103-53] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Monoclonal mSin3A antibody. Carrier free. Suitable for IP, Flow Cyt (Intra), WB and reacts with Human, Rat, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27103-53,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, IP, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMSin3A also known as Sin3A is a transcriptional corepressor that plays an important role in regulating gene expression. It weighs approximately 155 kDa. You can find mSin3A expressed in various tissues throughout the body. This protein does not bind DNA directly but associates with DNA-binding proteins to exert its effects. mSin3A functions mechanically by interacting with histone deacetylases (HDACs) leading to the remodeling of chromatin and repression of gene transcription.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMSin3A acts to regulate gene silencing and is a component of the mSin3A\/HDAC complex. This complex is involved in the control of cell cycle progression differentiation and apoptosis. In cellular processes mSin3A serves as a scaffold binding various proteins to create a platform for gene regulatory functions. Its role in recruiting HDACs to specific genomic locations aids in transcriptional repression affecting many biological processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nMSin3A plays significant roles in the Notch and p53 signaling pathways. These pathways are essential in controlling cell fate decisions and responses to stress. mSin3A partners with HDAC1 and HDAC2 within these pathways facilitating the deacetylation and repression of target genes. In the Notch signaling pathway mSin3A interacts with repressors like CSL while in the p53 pathway it influences p53-dependent transcriptional outcomes by modifying the chromatin state.\u003cbr\u003e\nMSin3A shows connection to cancer and neurodegenerative diseases. In cancer mSin3A affects tumor suppression through its interaction with p53 playing a role in cell cycle arrest and apoptosis. In neurodegenerative diseases mSin3A deregulation may disrupt chromatin architecture impairing neuronal function. By targeting mSin3A and associated proteins like HDAC1 researchers explore potential therapeutic avenues for these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860412551337,"sku":"ab307198","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab307198","provider":"Iright","version":"1.0","type":"link"}