{"product_id":"abcam-ab307554","title":"Abcam, ab307554, Anti-Swd2 antibody [EPR27034-63]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal Swd2 antibody. Suitable for IP, Flow Cyt (Intra), ICC\/IF, IHC-P, WB and reacts with Mouse, Human, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27034-63,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Mouse, Human,\u003cbr\u003e\nApplications:IP, Flow Cyt (Intra), IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSwd2 also known as Cwc21 or Swd2p is a protein that functions as a regulatory component in RNA splicing and transcription. This protein has a mass of approximately 47 kDa and is primarily expressed in the nucleus of eukaryotic cells. Swd2 associates with the spliceosome and transcription-related complexes playing a role in coordinating transcription and processing of RNA. Understanding its precise mechanical role is key to appreciate its broader biological implications.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSwd2 operates as part of the COMPASS complex a multiprotein assembly involved in histone modification. This complex methylates histone H3 at lysine 4 (H3K4) influencing chromatin structure and gene expression regulation. Swd2 contributes to the function of the spliceosome by interacting with core splicing machinery components aiding the removal of introns from pre-mRNA. Its activity affects gene expression patterns linking transcription processes with RNA maturation in the cell.\u003cbr\u003e\nPathways\u003cbr\u003e\nSwd2 is integral within two major biological pathways: RNA splicing and chromatin modification. Through RNA splicing it assists with the precise excision of introns interacting with proteins like Prp19. In the chromatin modification pathway it acts as part of the COMPASS complex which involves Set1 in the methylation of H3K4. This methylation is critical for chromatin remodeling therefore impacting transcription regulation and gene silencing.\u003cbr\u003e\nResearchers have noted associations between Swd2's function and certain cancers and neurodegenerative disorders. Aberrations in RNA splicing regulation where Swd2 is involved may contribute to oncogenesis. Altered Swd2 expression or function can disrupt the careful balance required for normal cell proliferation. Increased aberrant splicing or disrupted trimethylation at H3K4 potentially linked to Set1 may lead to pathways involved in these disorders. Understanding Swd2's pathways could be important for therapeutic exploration.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850310439081,"sku":"ab307554","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab307554","provider":"Iright","version":"1.0","type":"link"}