{"product_id":"abcam-ab307670","title":"Abcam, ab307670, Anti-HOPX\/HOD antibody [EPR27315-13]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HOPX\/HOD antibody. Suitable for WB, IHC-P, IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27315-13,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IP, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein HOPX also known as Homeodomain only protein is encoded by the HOPX gene. It is a small protein with a mass of approximately 8.5 kDa. HOPX is expressed in various tissues including cardiac myocytes epithelial tissues and stem cells. Known for its homeodomain-like structure HOPX does not bind DNA directly. Instead it influences transcription by interacting with other transcription factors and cofactors. The alternate name for HOPX is HOD and it serves as a reliable marker reflecting cellular differentiation and development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHOPX plays a role in regulating cell differentiation and tissue homeostasis. It acts without forming part of a larger protein complex primarily serving as a transcriptional regulator. This protein modulates the expression of genes critical for cell differentiation particularly in muscle and cardiac tissues. HOPX negatively regulates cell proliferation by modifying the transcription machinery influencing how cells enter mature states. Its role in differentiation makes it significant in both embryonic development and maintaining the integrity of adult cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nHOPX is significantly involved in the Wnt signaling pathway an important pathway in regulating cell fate across developmental stages. It modulates this pathway by interacting with proteins like β-catenin ensuring proper differentiation of various cell types. Another relevant pathway that includes HOPX is the BMP signaling pathway. Through this pathway HOPX contributes to osteogenesis and chondrogenesis working alongside proteins like SMADs which are effectors in the BMP pathway.\u003cbr\u003e\nHOPX has implications in cancer and heart disease. Aberrant HOPX expression can lead to cancer progression particularly in lung and colon cancers. It seems to act as a tumor suppressor and its interactions with proteins like p53 highlight its role in cancer biology. Additionally HOPX's regulation in cardiac development links it to congenital heart defects when mutations or misregulation occur. Understanding HOPX's interactions in these contexts offers potential therapeutic insights.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850264137897,"sku":"ab307670","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab307670","provider":"Iright","version":"1.0","type":"link"}