{"product_id":"abcam-ab307732","title":"Abcam, ab307732, Anti-LAGE-1 antibody [EPR27371-91]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal LAGE-1 antibody. Suitable for IP, IHC-P, WB and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27371-91,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLAGE-1 also known as CTAG2 is a cancer\/testis antigen that is expressed in tumors and normally only in the testis. Its precise molecular mass is approximately 22 kDa. LAGE-1 plays a mechanical role in cellular processes involving antigen presentation making it significant in the context of immune response modulation within neoplastic environments. The expression profile of LAGE-1 is characterized by its restriction to immune-privileged sites providing an opportunity for tumor-specific interventions due to its limited normal tissue expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLAGE-1 functions as part of a mechanism contributing to tumor immunogenicity. It participates in the presentation of peptides on the surface of cancer cells facilitating their recognition by T cells and subsequent immune targeting. LAGE-1 does not operate in isolation but may interact within a larger complex of similar antigens enhancing the immune system's ability to identify and combat malignancies.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of LAGE-1 in immune surveillance pathways is essential. It interacts with components of the major histocompatibility complex (MHC) class I antigen presentation pathway. By associating with proteins involved in this pathway LAGE-1 enhances the visibility of cancer cells to cytotoxic T lymphocytes. Other proteins such as LAGE-1's homolog MAGE-A share similar pathways suggesting overlapping roles in the formation of antigen complexes and subsequent immune recognition.\u003cbr\u003e\nLAGE-1 has strong associations with melanoma and non-small cell lung cancer. Its expression in these cancers makes it a target for immunotherapy approaches. In these contexts proteins like NY-ESO-1 which also belongs to the cancer\/testis antigen family are co-expressed with LAGE-1 indicating shared roles in tumor progression and immune evasion. These associations underline the potential of LAGE-1 as a marker for targeted cancer immunotherapy strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855883587753,"sku":"ab307732","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab307732","provider":"Iright","version":"1.0","type":"link"}